944351-60-4

Basic information

• Product Name: 1-(4-trifluoromethyl-phenyl)-cyclohexanecarbonitrile
• Synonyms: 1-(4-trifluoromethyl-phenyl)-cyclohexanecarbonitrile
• CAS NO: 944351-60-4
• Molecular Weight: 253.267
• Mol File: 944351-60-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(4-trifluoromethyl-phenyl)-cyclohexanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-trifluoromethyl-phenyl)-cyclohexanecarbonitrile(944351-60-4)
• EPA Substance Registry System: 1-(4-trifluoromethyl-phenyl)-cyclohexanecarbonitrile(944351-60-4)

Safety Data

• Hazardous Substances Data: 944351-60-4(Hazardous Substances Data)

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 2338-75-2 4-(Trifluoromethyl)phenylacetonitrile 
• 1309660-35-2 potassium 1-cyanocyclohexanecarboxylate 
• 146397-87-7 p-(trifluoromethyl)phenyl trifluoromethanesulfonate 
• 1130-21-8 ethyl 1-cyanocyclohexane-1-carboxylate 

Downstream Products

• 944351-61-5 1-(4-(trifluoromethyl)phenyl)cyclohexane-1-carbaldehyde 
• 944348-11-2 (1-(4-(trifluoromethyl)phenyl)cyclohexyl)methanamine 
• 1260786-37-5 C₁₄H₁₅F₃O₂ 

Relevant articles and documents

INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor

The current work discloses a novel cyclohexylarylamine chemotype with potent inhibition of the serotonin, norepinephrine, and dopamine transporters and potential for treatment of major depressive disorder. Optimized compounds 1 (SERT, NET, DAT, IC50 = 169, 85, 21 nM) and 42 (SERT, NET, DAT IC50 = 34, 295, 90 nM) were highly brain penetrant, active in vivo in the mouse tail suspension test at 30 mpk po and were not general motor stimulants.