945983-70-0

Basic information

• Product Name: 3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-ol
• Synonyms: 3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-ol
• CAS NO: 945983-70-0
• Molecular Weight: 242.2
• Mol File: 945983-70-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-ol(945983-70-0)
• EPA Substance Registry System: 3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-ol(945983-70-0)

Safety Data

• Hazardous Substances Data: 945983-70-0(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 2923-56-0 4-(trifluoromethyl)phenylhydrazine hydrochloride 
• 368-90-1 4-(trifluoromethyl)phenylhydrazine 

Downstream Products

• 233254-03-0 3-methyl-4-(trifluoroacetyl)-1-(4-trifluoromethylphenyl)pyrazol-5-one 
• 233254-01-8 1-(4-(trifluoromethyl)phenyl)-3-methyl-4-benzoyl-5-pyrazolone 
• 233254-02-9 1-(4-trifluoromethylphenyl)-3-methyl-4-acetyl-pyrazol-5-one 

Relevant articles and documents

Synthesis of Pyrazolofuropyrazine via One-Pot S N Ar Reaction and Intramolecular Direct C-H Arylation

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot S N Ar reaction/intramolecular C-H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.