946614-13-7

Basic information

• Product Name: 1-methoxy-3-(1,1,1-trifluoroprop-2-en-2-yl)benzene
• Synonyms: 1-methoxy-3-(1,1,1-trifluoroprop-2-en-2-yl)benzene
• CAS NO: 946614-13-7
• Molecular Weight: 202.176
• Mol File: 946614-13-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1-methoxy-3-(1,1,1-trifluoroprop-2-en-2-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxy-3-(1,1,1-trifluoroprop-2-en-2-yl)benzene(946614-13-7)
• EPA Substance Registry System: 1-methoxy-3-(1,1,1-trifluoroprop-2-en-2-yl)benzene(946614-13-7)

Safety Data

• Hazardous Substances Data: 946614-13-7(Hazardous Substances Data)

Upstream product

• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 2730-62-3 2-chloro-1,1,1-trifluoropropene 
• 10365-98-7 3-methoxyphenylboronic acid 
• 766-85-8 3-methoxy-1-iodobenzene 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Relevant articles and documents

Synthesis of α-trifluoromethylstyrene derivatives via Ni-catalyzed cross-coupling of 2-bromo-3,3,3-trifluoropropene and aryl Grignard reagents

The Ni-catalyzed cross-coupling of 2-bromo-3,3,3-trifluoropropene and aryl Grignard reagents was investigated. When NiCl2(PPh3)2 was used as a catalyst, the highest yield of α-trifluoromethylstyrene (89%) from 2-bromo-3,3,

Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol

Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant molecules. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy.

Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols

An unprecedented electrochemical heterodifunctionalization of α-CF3alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.