947503-92-6Relevant articles and documents
Lanthanide triflate catalysed reactions of acetals with primary amines and cascade cyclisation reactions
Heaney, Harry,Simcox, Michael T.,Slawin, Alexandra M.Z.,Giles, Robert G.
, p. 640 - 642 (1998)
The formation of imines from acetals and primary amines can be carried out at significantly lower temperatures using scandium or lanthanide triflates as catalysts, than in the absence of a catalyst: the intermediate aminol ethers can also take part in cascade cyclisation reactions, for example using tryptamine and ethyl tryptophanate.
A simple one-pot synthesis of 2,6-disubstituted 4-(polyfluoroalkyl) pyridines and -pyrimidines by reaction of 2-polyfluoroalkylchromones with aromatic methyl ketimines and amidines
Sosnovskikh, Vyacheslav Ya.,Usachev, Boris I.,Sizov, Aleksei Yu.,Barabanov, Mikhail A.
, p. 942 - 948 (2007/10/03)
The reaction of 2-polyfluoroalkylchromones with ketimines, derived from aromatic methyl ketones and isopropylamine, gives 2,6-diaryl-4- polyfluoroalkylpyridines in moderate to low yields. Benzamidine and guanidine also react with 2-polyfluoroalkylchromones to afford the corresponding 2,6-disubstituted 4-polyfluoroalkylpyrimidines.
