949152-13-0

Basic information

• Product Name: (rac)-3-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-4-oxopiperidine-1-carboxylic acid tert-butyl ester
• Synonyms: (rac)-3-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-4-oxopiperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 949152-13-0
• Molecular Weight: 464.989
• Mol File: 949152-13-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 597.9±50.0 °C(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (rac)-3-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-4-oxopiperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (rac)-3-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-4-oxopiperidine-1-carboxylic acid tert-butyl ester(949152-13-0)
• EPA Substance Registry System: (rac)-3-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-4-oxopiperidine-1-carboxylic acid tert-butyl ester(949152-13-0)

Safety Data

• Hazardous Substances Data: 949152-13-0(Hazardous Substances Data)

Upstream product

• 921630-23-1 N-[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropanamine 
• 220389-30-0 1-tert-butyl 3-methyl 4-hydroxy-5,6-dihydropyridine-1,3(2H)-dicarboxylate 
• 98977-34-5 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate 
• 161491-24-3 methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate 

Downstream Products

• 949152-19-6 C₄₀H₄₉Cl₃N₄O₆ 

Relevant articles and documents

Piperidine-based renin inhibitors: Upper chain optimization

The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor wi

3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

AMINES

The invention relates to novel amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.