949237-99-4

Basic information

• Product Name: 3-[5-(ethoxycarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]propanoic acid
• Synonyms: 3-[5-(ethoxycarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]propanoic acid
• CAS NO: 949237-99-4
• Molecular Weight: 332.356
• Mol File: 949237-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[5-(ethoxycarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[5-(ethoxycarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]propanoic acid(949237-99-4)
• EPA Substance Registry System: 3-[5-(ethoxycarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]propanoic acid(949237-99-4)

Safety Data

• Hazardous Substances Data: 949237-99-4(Hazardous Substances Data)

Upstream product

• 462-88-4 N-carbamoyl-β-alanine 
• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Protecting group free synthesis of carboxyl-substituted dihydropyrimidines through Biginelli reaction

Chlorotrimethylsilane-promoted Biginelli-type reaction of benzaldehyde, acetoacetic acid derivatives, and various carboxyl-containing ureas was explored. It was found that the steric load of the urea substituents influenced strongly the reaction outcome; in particular, the method was efficient only in the case of unbranched mono-substituted ureas bearing either aliphatic or aromatic groups. The method allows performing a one-pot, protecting group free synthesis of dihydropyrimidines possessing carboxylic functionality.