951626-38-3Relevant articles and documents
Further optimization of the M1PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration
Panarese, Joseph D.,Cho, Hykeyung P.,Adams, Jeffrey J.,Nance, Kellie D.,Garcia-Barrantes, Pedro M.,Chang, Sichen,Morrison, Ryan D.,Blobaum, Anna L.,Niswender, Colleen M.,Stauffer, Shaun R.,Conn, P. Jeffrey,Lindsley, Craig W.
, p. 3822 - 3825 (2016)
This Letter describes the continued chemical optimization of the VU0453595 series of M1positive allosteric modulators (PAMs). By surveying alternative 5,6- and 6,6-heterobicylic cores for the 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one core of