95215-73-9

Basic information

• Product Name: 2,5-Pyrrolidinedione, 1-[[[2-oxo-3-(phenylmethoxy)-1(2H)-pyridinyl]acetyl]oxy]-
• CAS NO: 95215-73-9
• Molecular Formula: C18H16N2O6
• Molecular Weight: 356.335
• Mol File: 95215-73-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,5-Pyrrolidinedione, 1-[[[2-oxo-3-(phenylmethoxy)-1(2H)-pyridinyl]acetyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyrrolidinedione, 1-[[[2-oxo-3-(phenylmethoxy)-1(2H)-pyridinyl]acetyl]oxy]-(95215-73-9)
• EPA Substance Registry System: 2,5-Pyrrolidinedione, 1-[[[2-oxo-3-(phenylmethoxy)-1(2H)-pyridinyl]acetyl]oxy]-(95215-73-9)

Safety Data

• Hazardous Substances Data: 95215-73-9(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 95215-72-8 2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid 
• 100-44-7 benzyl chloride 
• 95215-70-6 1-ethoxycarbonylmethyl-3-hydroxy pyrid-2-one 
• 84719-32-4 3-Hydroxy-2(1H)-pyridinone 

Downstream Products

• 99110-76-6 N,N,N-tris<2-(3-hydroxy-2-oxo-1,2-dihydropyridin-1-yl)acetamido>ethylamine 
• 95215-76-2 2-(3-Benzyloxy-2-oxo-2H-pyridin-1-yl)-N-methyl-acetamide 
• 95215-82-0 2-(3-Benzyloxy-2-oxo-2H-pyridin-1-yl)-N-butyl-acetamide 
• 95215-80-8 2-(3-Benzyloxy-2-oxo-2H-pyridin-1-yl)-N-isopropyl-acetamide 
• 95215-74-0 2-(3-Benzyloxy-2-oxo-2H-pyridin-1-yl)-N-ethyl-acetamide 
• 126328-33-4 2-(3-Benzyloxy-2-oxo-2H-pyridin-1-yl)-N-[3-(bis-{3-[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)-acetylamino]-propyl}-amino)-propyl]-acetamide 
• 99110-77-7 N,N,N-tris<2-(3-benzyloxy-2-oxo-1,2-dihydropyridin-1-yl)acetamido>ethylamine 

Relevant articles and documents

Novel 3-hydroxy-2(1H)-pyridinones. Synthesis, iron(III)-chelating properties, and biological activity

The synthesis of a range of novel bidentate and hexadentate ligands containing the chelating moiety 3-hydroxy-2(1H)-pyridinone is described. The pK(a) values of the ligands and the stability constants of their iron(III) complexes have been determined. The stability constant of the iron(III) complex of one of the hexadentate ligands is comparable to that of desferrioxamine B. The distribution coefficients of the ligands and their iron(III) complexes were also determined. One of the novel hexadentate compounds has been shown to markedly enhance iron(III) excretion from both hepatocytes and iron-overloaded mice.

Pharmaceutical compositions

Pharmaceutical compositions containing a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, or a salt thereof containing a physiologically acceptable ion or ions, are of value for removing toxic amounts of metals, particularly iron, from the body.