952487-00-2

Basic information

• Product Name: C₂₉H₃₄N₆O₈
• CAS NO: 952487-00-2
• Molecular Weight: 594.624
• Mol File: 952487-00-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₄N₆O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₄N₆O₈(952487-00-2)
• EPA Substance Registry System: C₂₉H₃₄N₆O₈(952487-00-2)

Safety Data

• Hazardous Substances Data: 952487-00-2(Hazardous Substances Data)

Upstream product

• 71989-16-7 Fmoc-Asn-OH 
• 86123-10-6 Fmoc-D-Phe-OH 
• 104090-93-9 N-Fmoc-D-Glu α-amide γ-tert-butyl ester 
• 163619-04-3 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan 

Relevant articles and documents

Tetrapeptide inhibitors of the glutamate vesicular transporter (VGLUT)

Quinoline-2,4-dicarboxylic acids (QDCs) bearing lipophilic substituents in the 6- or 7-position were shown to be inhibitors of the glutamate vesicular transporter (VGLUT). Using the arrangement of the QDC lipophilic substituents as a template, libraries of X1X2EF and X1X2EW tetrapeptides were synthesized and tested as VGLUT inhibitors. The peptides QIEW and WNEF were found to be the most potent. Further stereochemical deconvolution of these two peptides showed dQlIdElW to be the best inhibitor (Ki = 828 ± 252 μM). Modeling and overlay of the tetrapeptide inhibitors with the existing pharmacophore showed that H-bonding and lipophilic residues are important for VGLUT binding.