953090-94-3

Basic information

• Product Name: [2-(tetrahydro-pyran-2-yloxy)-5-trifluoromethyl-phenyl]-methanol
• Synonyms: [2-(tetrahydro-pyran-2-yloxy)-5-trifluoromethyl-phenyl]-methanol
• CAS NO: 953090-94-3
• Molecular Weight: 276.256
• Mol File: 953090-94-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(tetrahydro-pyran-2-yloxy)-5-trifluoromethyl-phenyl]-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(tetrahydro-pyran-2-yloxy)-5-trifluoromethyl-phenyl]-methanol(953090-94-3)
• EPA Substance Registry System: [2-(tetrahydro-pyran-2-yloxy)-5-trifluoromethyl-phenyl]-methanol(953090-94-3)

Safety Data

• Hazardous Substances Data: 953090-94-3(Hazardous Substances Data)

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 888972-21-2 2-tetrahydropyran-2-yloxy-5-(trifluoromethyl)benzaldehyde 
• 110-87-2 3,4-dihydro-2H-pyran 
• 134142-88-4 2-[(4-trifluoromethyl)phenoxy]tetrahydro-2H-pyrane 

Downstream Products

• 953090-93-2 2-(2-butoxymethyl-4-trifluoromethyl-phenoxy)-tetrahydropyran 

Relevant articles and documents

Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

The long chain free fatty acid receptor 4 (FFA4/GPR120) has recently been recognized as lipid sensor playing important roles in nutrient sensing and inflammation and thus holds potential as a therapeutic target for type 2 diabetes and metabolic syndrome. To explore the effects of stimulating this receptor in animal models of metabolic disease, we initiated work to identify agonists with appropriate pharmacokinetic properties to support progression into in vivo studies. Extensive SAR studies of a series of phenylpropanoic acids led to the identification of compound 29, a FFA4 agonist which lowers plasma glucose in two preclinical models of type 2 diabetes.