956-92-3

Basic information

• Product Name: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-
• CAS NO: 956-92-3
• Molecular Formula: C14H10ClNO2
• Molecular Weight: 259.692
• Mol File: 956-92-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-(956-92-3)
• EPA Substance Registry System: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-(956-92-3)

Safety Data

• Hazardous Substances Data: 956-92-3(Hazardous Substances Data)

Usage

Description

1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-, also known as Clonitazene, is a synthetic opioid analgesic and sedative drug. It belongs to the benzimidazole chemical class and is structurally related to fentanyl and other opioid drugs. Clonitazene is a potent analgesic, and it has been found to produce effects similar to those of morphine. However, it has a shorter duration of action and is less likely to cause respiratory depression.

Uses

Used in Pharmaceutical Industry:
Clonitazene is used as an analgesic agent for the management of moderate to severe pain. Its potent analgesic effects and shorter duration of action make it a potential alternative to other opioid drugs like morphine.
Used in Research:
Clonitazene is used for research purposes to study the effects and mechanisms of action of synthetic opioids. It can help in understanding the potential therapeutic applications and risks associated with the use of such drugs.
Note: Clonitazene is a controlled substance in many countries due to its potential for abuse and dependence. It is not approved for medical use.

Upstream product

• 55275-44-0 4'-chloro-o-benzoylbenzoic acid chloride 
• 106-39-8 bromochlorobenzene 
• 136918-14-4 phthalimide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 85-56-3 2-(4-chlorobenzoyl)benzoic acid 

Downstream Products

• 131-09-9 2-chloroanthracene-9,10-dione 
• 1610474-65-1 C₂₈H₁₈ClNO 
• 38046-68-3 3-(4-chlorophenyl)benzo[c]isoxazole 

Relevant articles and documents

Asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxy-isoindolin-1-ones employing SPINOL-derived chiral phosphoric acid

The asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxyisoindolin-1-ones has been developed employing SPINOL-derived phosphoric acid and a high steric demand Hantzsch ester as the hydrogen source. The corresponding products are obtained in good yields and up to 93% enantioselectivities.

Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N-Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones

The rhodium(III)-catalyzed redox-neutral coupling reaction of N-acyl ketimines generated in situ from 3-hydroxyisoindolinones with various activated olefins is described. This approach leads to the synthesis of bioactive spiroisoindolinone derivatives in

Hydroxorhodium/chiral diene complexes as effective catalysts for the asymmetric arylation of 3-aryl-3-hydroxyisoindolin-1-ones

Water is out, aryl is in! Asymmetric synthesis of isoindoline-1-ones bearing an α-triaryl-substituted stereogenic center was realized in the enantioselective addition of arylboroxines to 3-aryl-3-hydroxyisoindolin-1-ones in the presence of a hydroxorhodium/chiral diene catalyst, where cyclic N-carbonyl ketimines were generated in situ by dehydration. Copyright