956807-07-1

Basic information

• Product Name: 3-(p-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile
• Synonyms: 3-(p-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile
• CAS NO: 956807-07-1
• Molecular Weight: 290.281
• Mol File: 956807-07-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(p-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(p-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile(956807-07-1)
• EPA Substance Registry System: 3-(p-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile(956807-07-1)

Safety Data

• Hazardous Substances Data: 956807-07-1(Hazardous Substances Data)

Upstream product

• 77635-72-4 1-(4-nitro-phenyl)-ethanone-phenylhydrazone 
• 21487-49-0 3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehydes

A new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-Triazolidine-3-Thiones, and Knoevenagel condensation products was synthesized from 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested in vitro for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans in comparison with imipenem (intravenous β-lactam antibiotic) and clotrimazole (antifungal medication) as reference drugs by using the agar diffusion technique. 3-Aryl-1-phenyl-1H-pyrazole-4-carbonitriles 8b, 8c, and 8d showed significant antifungal activity against the fungus C. albicans.

Highly Efficient Microwave-assisted One-Pot Synthesis of Aromatic Nitriles from Aromatic Aldehydes

A highly efficient and environmentally benign protocol is described for the microwave-assisted one-pot synthesis of aromatic nitriles from aromatic aldehydes by the reaction with hydroxylamine hydrochloride in DMSO, which involves the intermediate formation of aldoximes and subsequent dehydration. The developed synthetic methodology can be readily accomplished with various aldehydes containing both electron-donor and electron-acceptor groups, providing excellent yields of the target products in shorter reaction times (1–2 min) compared to previously reported methodologies.