95794-11-9

Basic information

• Product Name: (1,3-BENZODIOXOL-5-YLMETHYLENE)(PHENYL)AZANE OXIDE
• Synonyms: (1,3-BENZODIOXOL-5-YLMETHYLENE)(PHENYL)AZANE OXIDE
• CAS NO: 95794-11-9
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.24
• Mol File: 95794-11-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1,3-BENZODIOXOL-5-YLMETHYLENE)(PHENYL)AZANE OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (1,3-BENZODIOXOL-5-YLMETHYLENE)(PHENYL)AZANE OXIDE(95794-11-9)
• EPA Substance Registry System: (1,3-BENZODIOXOL-5-YLMETHYLENE)(PHENYL)AZANE OXIDE(95794-11-9)

Safety Data

• Hazardous Substances Data: 95794-11-9(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 100-65-2 N-Phenylhydroxylamine 
• 98-95-3 nitrobenzene 
• 586-96-9 Nitrosobenzene 

Downstream Products

• 21355-10-2 (3-benzo[1,3]dioxol-5-yl-2,4,4-triphenyl-isoxazolidin-5-ylidene)-(4-bromo-phenyl)-amine 
• 1410877-04-1 C₃₁H₂₃NO₂ 
• 1410877-07-4 C₃₁H₂₃NO₂ 
• 100937-73-3 (3R,3aS,6aR)-3-Benzo[1,3]dioxol-5-yl-2,5-diphenyl-tetrahydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 100858-30-8 (3S,3aS,6aR)-3-Benzo[1,3]dioxol-5-yl-2,5-diphenyl-tetrahydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 213609-34-8 2-chloro-4-[2,4-diphenyl-3-(3,4-methylenedioxyphenyl)-3H-triazolidine-5-on-1-yl]quinoline-3-carbonitrile 

Relevant articles and documents

Metal-free approach for the ?-proline mediated synthesis of nitrones from nitrosobenzene

An efficient, and metal-free approach for the ?-proline mediated synthesis of nitrones from nitrosobenzene and benzaldehydes has been established. The reaction undergoes very efficiently at room temperature in methanol as a solvent. The reaction is assumed to involve that the initial formation of azomethine ylide and [2 + 3] cycloaddition of nitrosobenzene, followed by the subsequent retro [2 + 3] cycloaddition could offer the desired nitrone.

α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus

Nitrone-containing compounds are commonly employed as spin traps of free radical species in chemical and biological studies. Some molecules as α-phenyl-N-t-butyl nitrone (PBN) and its derivatives have been tested as potential drugs to treat oxidative stress related diseases, as Alzheimer and stroke for example. In this work we report the design and the synthesis of α-aryl-N-aryl nitrones and their cytoprotection profile on human neuroblastoma cells (SH-SY5Y) under induced oxidative stress. All the nine synthesized nitrones showed a significant response at low micromolar concentration. The selected compound 8 (α-phenyl-N-phenyl nitrone) increased the reduced glutathione (GSH) levels by 65% and lowered the necrotic cell death from 25.8% to 3.8%. Based on our data, the designed highly conjugated nitrone double-bond skeleton can be considered as a good scaffold for further studies regarding oxidative stress-related diseases.

Synthesis of C, N-diaryl nitrones from the reduction of nitroarene with aromatic aldehydes promoted by metallic samarium

A mild and facile reduction of nitroarene with aromatic aldehydes promoted by metallic samarium to C, N-diaryl nitrones in moderate yields has been developed.