96-02-6

Basic information

• Product Name: CHLOROMALEIC ACID ANHYDRIDE
• Synonyms: CHLOROMALEIC ACID ANHYDRIDE;3-chloro-5-furandione;chloromaleicanhydride;MONO-CHLOROMALEIC ANHYDRIDE;3-Chloro-2,5-furandione;3-Chlorofuran-2,5-dione;2-Chloromaleic anhydride
• CAS NO: 96-02-6
• Molecular Formula: C₄HClO₃
• Molecular Weight: 132.5
• EINECS: 202-470-4
• Mol File: 96-02-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 33°C
• Boiling Point: 173.21°C (rough estimate)
• Flash Point: 95.5 °C
• Appearance: /
• Density: 1.5375
• Vapor Pressure: 0.408mmHg at 25°C
• Refractive Index: 1.4980 (estimate)
• CAS DataBase Reference: CHLOROMALEIC ACID ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROMALEIC ACID ANHYDRIDE(96-02-6)
• EPA Substance Registry System: CHLOROMALEIC ACID ANHYDRIDE(96-02-6)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 96-02-6(Hazardous Substances Data)

Usage

Description

Chloromaleic Acid Anhydride is an organic compound characterized by the presence of a chloro group and a maleic anhydride moiety. It is a versatile reagent used in various chemical reactions and synthesis processes due to its unique chemical properties.

Uses

Used in Chemical Synthesis:
Chloromaleic Acid Anhydride is used as a reagent in the metal hydride reduction of unsymmetrically substituted cyclic anhydrides. This application is crucial for the synthesis of various organic compounds and pharmaceutical intermediates, as it allows for the selective reduction of specific functional groups within complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Chloromaleic Acid Anhydride is utilized as a key intermediate in the synthesis of certain drugs and drug candidates. Its unique structure and reactivity enable the development of novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Research and Development:
Chloromaleic Acid Anhydride is also employed in research and development settings, where it serves as a valuable tool for exploring new chemical reactions and mechanisms. Its use in these contexts contributes to the advancement of scientific knowledge and the discovery of innovative materials and compounds.

InChI:InChI=1/C4HClO3/c5-2-1-3(6)8-4(2)7/h1H

Upstream product

• 108-31-6 maleic anhydride 
• 617-43-6 2-chloromaleic acid 
• 617-42-5 chlorofumaric acid 
• 17096-37-6 chlorofumaryl chloride 
• 3856-37-9 (2R,3S)-2,3-Dichloro-succinic acid 
• 108-24-7 acetic anhydride 
• 108-30-5 succinic acid anhydride 
• 7782-50-5 chlorine 
• 7705-08-0 iron(III) chloride 
• 42595-14-2 (2R*,3R*)-2,3-Dichlorosuccinic anhydride 
• 108-90-7 chlorobenzene 
• 88497-26-1 2-bromo-3-chloro-succinic acid 
• 89180-55-2 2,3,4,4,4-pentachloro-butyric acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 19393-45-4 dimethyl chloromaleate 
• 22801-46-3 chloromaleic acid dipropyl ester 
• 626-10-8 chloro-maleic acid diethyl ester 
• 80546-38-9 4,5-diphenyl-3,6-di-p-tolyl-phthalic acid-anhydride 
• 103282-40-2 4,5-bis-(4-methoxy-phenyl)-3,6-diphenyl-phthalic acid-anhydride 
• 60387-49-7 4,5-diphenylphthalic anhydride 
• 340-17-0 3-(4-fluoro-phenyl)-4,5,6-triphenyl-phthalic acid-anhydride 

Relevant articles and documents

Method for preparing 2-chloromaleic anhydride

The invention relates to the technical field of organic synthesis, in particular to a method for preparing 2-chloromaleic anhydride, which comprises the following steps of adding maleic anhydride intoa reaction bottle, heating until the solid is molten, adding ferric trichloride, and pumping the reaction solution into a mixing module by using a pump, introducing chlorine into the mixing module, heating the micro-channel reaction module, and enabling reaction liquid in the mixing module to pass through the micro-channel reaction module at a certain flow rate, then connecting a micro-reactor with a fixed bed, heating the micro-reactor, introducing the reaction liquid passing through the micro-channel reactor into the fixed bed micro-reactor for reaction by adopting a mixed catalyst consisting of barium chloride and activated carbon, introducing nitrogen at a certain rate, taking away hydrogen chloride gas generated by the reaction, and collecting the reaction liquid, and distilling to obtain the 2-chloromaleic anhydride. The mixed catalyst composed of barium chloride and activated carbon is adopted, the reaction speed is high, the product yield and purity are high, and the requirement for equipment is lowered.

CRYSTAL STRUCTURE OF N-(2,6-DIMETHYLPHENYL)CHLOROMALEINIMIDE

The crystal structure of N-(2,6-dimethylphenyl)chloromaleinimide solved by the heavy atom method was refined by the 9*9 block-diagonal matrix least squares method to a final R value 0.08 for 1147 observed diffractions.The compound crystallizes in the orthorhombic system with Pbca group and lattice parameters a=13.622(4), b=13.483(7), c=12.768(6) Angstroem, Z=8.Monomeric units, between which interactions of type Cl...H-C and O...H-C occured, formed the crystal structure.Both moieties of the molecule, i.e. the phenyl and the five-membered maleinimide rings were foundto be virtually planar and the central planes intersecting these rings form an angle 78.3 deg.