965-93-5 Usage
Description
Methyltrienolone, also known as R1881 or 17α-Methyl-19-nortestosterone, is a synthetic anabolic-androgen steroid derived from nandrolone (19-nortestosterone). It is a 17α-alkylated compound with potent androgenic and anabolic effects. However, due to its strong side effects and liver toxicity, it is not sold as a prescription drug or dietary supplement. Instead, Methyltrienolone is commonly used as a reference point for in vitro biological activity in biochemical studies, as it can bind strongly to the androgen receptor.
Uses
Used in Biochemical Research:
Methyltrienolone is used as a reference compound for in vitro biological activity studies, particularly in assessing the potency and efficacy of other anabolic and androgenic agents. Its strong binding affinity to the androgen receptor makes it a valuable tool for understanding the mechanisms of action and potential therapeutic applications of related compounds.
Used in Drug Development:
Methyltrienolone can be used as an affinity label of the androgen receptor in the prostate and in prostatic tumors. This application aids in the development of novel drugs targeting the androgen receptor, which may have potential therapeutic benefits in the treatment of prostate cancer and other androgen-dependent conditions.
Used in Analytical Chemistry:
Due to its unique chemical properties and strong binding to the androgen receptor, Methyltrienolone can be employed as a standard or reference compound in analytical chemistry for the development and validation of assays and methods for detecting and quantifying anabolic and androgenic steroids in biological samples.
Biochem/physiol Actions
Androgen receptors (ARs) are nuclear hormone receptors/transcription factors. R1881, also known as methyltrienolone, is a synthetic androgen. It is the gold standard AR agonist.
References
https://en.wikipedia.org/wiki/Metribolone
https://www.drugbank.ca/drugs/DB02998
https://pubchem.ncbi.nlm.nih.gov/compound/Methyltrienolone
Kazlauskas R. (2010) Designer Steroids. In: Thieme D., Hemmersbach P. (eds) Doping in Sports: Biochemical Principles, Effects and Analysis. Handbook of Experimental Pharmacology, vol 195. Springer, Berlin, Heidelberg
Check Digit Verification of cas no
The CAS Registry Mumber 965-93-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,6 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 965-93:
(5*9)+(4*6)+(3*5)+(2*9)+(1*3)=105
105 % 10 = 5
So 965-93-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H24O2/c1-18-9-7-15-14-6-4-13(20)11-12(14)3-5-16(15)17(18)8-10-19(18,2)21/h7,9,11,16-17,21H,3-6,8,10H2,1-2H3/t16-,17+,18+,19+/m1/s1
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