97-05-2

Basic information

• Product Name: Sulfosalicylic acid
• Synonyms: 5-Sulfosalicylic;Benzoic acid, 2-hydroxy-5-sulfo-;3-CARBOXY-4-HYDROXYBENZENESULFONIC ACID,99%;2-Hydroxy-5-sulfo-benzoic acid;2-Hydroxy-5-(hydroxysulfonyl)benzoic acid;2-Hydroxy-5-sulfobenzenecarboxylic acid;6-Hydroxy-3-sulfobenzoic acid;5-Sulfosalicylic Acid (5-SSA)
• CAS NO: 97-05-2
• Molecular Formula: C₇H₆O₆S
• Molecular Weight: 218.18
• EINECS: 202-555-6
• Mol File: 97-05-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 120°C
• Boiling Point: 328.86°C (rough estimate)
• Appearance: Clear/Liquid
• Density: 1.7563 (rough estimate)
• Vapor Pressure: 0.005Pa at 20℃
• Refractive Index: 1.5300 (estimate)
• PKA: -0.62±0.50(Predicted)
• Water Solubility: 987g/L at 20℃
• CAS DataBase Reference: Sulfosalicylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfosalicylic acid(97-05-2)
• EPA Substance Registry System: Sulfosalicylic acid(97-05-2)

Safety Data

• RIDADR: UN 1760
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 97-05-2(Hazardous Substances Data)

Usage

Description

Sulfosalicylic acid is an arenesulfonic acid that is a benzoic acid derivative with acetylcholinesterase inhibitory properties. It is characterized by the presence of a hydroxy group at position C-2 and a sulfo group at C-5. Sulfosalicylic acid is a colorless crystalline solid that turns pink upon exposure to traces of iron. It is highly soluble in water.

Uses

Used in Pharmaceutical Industry:
Sulfosalicylic acid is used as an acetylcholinesterase inhibitor, which can help in the treatment of various neurological disorders by increasing the levels of acetylcholine in the brain.
Used in Chemical Analysis:
Sulfosalicylic acid is used as a reagent for albumin and a colorimetric reagent for ferric ions. It helps in the detection and quantification of these substances in various samples.
Used in Dye Industry:
Sulfosalicylic acid is used as an intermediate for the synthesis of dyes. It plays a crucial role in the production of various types of dyes used in different industries.
Used in Surfactant Production:
Sulfosalicylic acid is used as an intermediate in the production of surfactants. Surfactants are compounds that lower the surface tension between two liquids or between a liquid and a solid, and are widely used in detergents, cleaners, and other products.
Used in Catalyst Production:
Sulfosalicylic acid is used as a catalyst in various chemical reactions. Catalysts are substances that increase the rate of a chemical reaction without being consumed in the process.
Used in Grease Additive Industry:
Sulfosalicylic acid is used as a grease additive to improve the performance and stability of greases used in various applications, such as lubrication and protection of machinery and equipment.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C7H8O4S/c8-7-4-2-1-3-6(7)5-12(9,10)11/h1-4,8H,5H2,(H,9,10,11)

Synthetic route

phenyl Salicylate (118-55-8) → 5-sulfosalicylic Acid (97-05-2)

Conditions	Yield
With sulfuric acid

salicylic acid (69-72-7) → 5-sulfosalicylic Acid (97-05-2)

Conditions	Yield
With sulfuric acid
With sulfur trioxide
With sulfuric acid
With sulfuric acid Abpressen des entstandenen Krystallbreis und Eintragen in gesaettigte Kochsalzloesung;
With chlorosulfonic acid at 160℃; Zersetzung des Produktes mit Wasser;

2-oxo-2H-chromene-6-sulfonic acid (27279-86-3) + alkaline permanganate solution → 5-sulfosalicylic Acid (97-05-2)

2-oxo-2H-chromene-3,6-disulfonic acid (69089-38-9) + alkaline permanganate solution → 5-sulfosalicylic Acid (97-05-2)

4-methyl-2-oxo-2H-chromene-6-sulfonic acid + permanganate + barytesalkali → 5-sulfosalicylic Acid (97-05-2)

4-methyl-2-oxo-2H-chromene-3,6-disulfonic acid + permanganate + barytesalkali → 5-sulfosalicylic Acid (97-05-2)

phenyl Salicylate (118-55-8) + sulfuric acid (excess) → 5-sulfosalicylic Acid (97-05-2)

chlorosulfonic acid (7790-94-5) + salicylic acid (69-72-7) → 5-sulfosalicylic Acid (97-05-2)

Conditions	Yield
at 160℃;

sulfuric acid (7664-93-9) + salicylic acid (69-72-7) → 5-sulfosalicylic Acid (97-05-2)

sulfur trioxide (7446-11-9) + salicylic acid (69-72-7) → 5-sulfosalicylic Acid (97-05-2)

coumarin-disulfonic acid-(3.6) → 5-sulfosalicylic Acid (97-05-2)

Conditions	Yield
With potassium hydroxide; permanganate(VII) ion

coumarin-sulfonic acid-(6) → 5-sulfosalicylic Acid (97-05-2)

Conditions	Yield
With potassium hydroxide; permanganate(VII) ion

monopotassium-salt of/the/ 6-bromo-3-sulfo-benzoic acid → 5-sulfosalicylic Acid (97-05-2)

Conditions	Yield
With water; copper; potassium carbonate at 170℃;

monopotassium-salt of/the/ 6-chloro-3-sulfo-benzoic acid → 5-sulfosalicylic Acid (97-05-2)

Conditions	Yield
With water; copper; potassium carbonate at 170℃;

5-sulpho-2-hydroxybenzaldehyde (25149-61-5) + silver oxide → 5-sulfosalicylic Acid (97-05-2)

2-hydroxy-5-methoxysulfonylbenzoicacid methyl ester (83957-15-7) + alcoholic KOH-solution → 5-sulfosalicylic Acid (97-05-2)

hydrogenchloride (7647-01-0) + ethanol (64-17-5) + diboric acid-1,2-bis-(2-carboxy-4-sulfo-phenyl ester); disodium salt → metaboric acid (13460-50-9) + 5-sulfosalicylic Acid (97-05-2)

5-sulfosalicylic Acid (97-05-2) → 3-bromo-2-hydroxy-5-sulfobenzoic acid (50390-26-6)

Conditions	Yield
With bromine In water	100%
With water; bromine

5-sulfosalicylic Acid (97-05-2) + (S)-(+)-clopidogrel (113665-84-2) → methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate 5-sulfosalicylate (1010080-15-5)

Conditions	Yield
In methanol at 30℃; for 0.5h;	100%
In dichloromethane at 20℃; for 0.5 - 1h; Product distribution / selectivity; Heating / reflux;	100%

methanol (67-56-1) + 5-sulfosalicylic Acid (97-05-2) → 5-sulfosalicylic methyl ester (92333-05-6)

Conditions	Yield
for 18h; Reflux;	100%

p-aminobenzamidine (3858-83-1) + 5-sulfosalicylic Acid (97-05-2) → 4-aminobenzamidinium bis(5-sulfosalicylate)monohydrate

Conditions	Yield
With water In methanol	95%

2-amino-3-benzyloxypyridine (24016-03-3) + 5-sulfosalicylic Acid (97-05-2) → C12H12N2O*C7H6O6S

Conditions	Yield
In ethanol for 3h; Reflux;	95%

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (58-08-2) + 5-sulfosalicylic Acid (97-05-2) → 2-Hydroxy-5-sulfo-benzoic acid; compound with 1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione (60473-74-7)

Conditions	Yield
In methanol; water at 20℃; for 0.5h;	94.36%

copper diacetate (142-71-2) + 1,5-diamino-3-azapentane (111-40-0) + 5-sulfosalicylic Acid (97-05-2) → Cu(2+)*2(O3SC6H3OCOO)Cu(C4H13N3)(H2O)(1-)*6H2O = Cu[(O3SC6H3OCOO)Cu(C4H13N3)(H2O)]2*6H2O

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/triamine/salicylic acid molar ratio 3:2:2; refluxing (2 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	94%

pentaphenylphosphorane (2588-88-7) + 5-sulfosalicylic Acid (97-05-2) → tetraphenylphosphonium sulfosalicylate

Conditions	Yield
In benzene at 80℃; for 0.166667h;	93%

5-sulfosalicylic Acid (97-05-2) + 6-amino-5-nitro-2-picoline (21901-29-1) → C6H7N3O2*C7H6O6S

Conditions	Yield
In ethanol for 3h; Reflux;	93%

nickel diacetate (373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6) + 1,5-diamino-3-azapentane (111-40-0) + 5-sulfosalicylic Acid (97-05-2) → Ni(2+)*2(O3SC6H3OCOO)Ni(C4H13N3)(H2O)(1-)*6H2O = Ni[(O3SC6H3OCOO)Ni(C4H13N3)(H2O)]2*6H2O

Conditions	Yield
In N,N-dimethyl-formamide Ni-salt/triamine/salicylic acid molar ratio 3:2:2; refluxing (2.5 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	92%

copper diacetate (142-71-2) + 1,5-diamino-3-azapentane (111-40-0) + 5-sulfosalicylic Acid (97-05-2) → Cu(C4H13N3)(H2O)3(2+)*2(O3SC6H3OCOO)Cu(C4H13N3)(H2O)(1-)*5H2O = [Cu(C4H13N3)(H2O)3][(O3SC6H3OCOO)Cu(C4H13N3)(H2O)]2*5H2O

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/triamine/salicylic acid molar ratio 3:3:2; refluxing; recrystn. (water), drying (room temp., red. pressure); elem. anal.;	92%

5-sulfosalicylic Acid (97-05-2) + aripiprazole (129722-12-9) → 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone 5-sulfosalicylate (1246273-26-6)

Conditions	Yield
In chloroform for 2h; Product distribution / selectivity; Reflux;	91%

pentaphenylantimony (2170-05-0) + 5-sulfosalicylic Acid (97-05-2) → tetraphenylstibonium sulfosalicylate (194939-13-4)

Conditions	Yield
In ethanol; toluene byproducts: C6H6; room temp., several min; evapn., recrystn. (ethanol-water, 5:1);	90.6%

pentaphenylantimony (2170-05-0) + 5-sulfosalicylic Acid (97-05-2) → 5-(tetraphenylantimoniooxysulfonyl)salicylic acid (194939-13-4)

Conditions	Yield
In ethanol; toluene soln. of Sb-compd. in toluene addn. to ethanolic soln. of acid, standingat room temperature for few minutes; solvent removing, residue re-crystn. (ethanol-water);	90.6%

copper diacetate (142-71-2) + 1,5-diamino-3-azapentane (111-40-0) + 5-sulfosalicylic Acid (97-05-2) → Cu(C4H13N3)2(2+)*2(O3SC6H3OCOO)Cu(C4H13N3)(H2O)(1-)*10H2O = [Cu(C4H13N3)2][(O3SC6H3OCOO)Cu(C4H13N3)(H2O)]2*10H2O

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/triamine/salicylic acid molar ratio 3:4:2; refluxing (2 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	90%

N,N'-dimethylpiperazine (106-58-1) + 5-sulfosalicylic Acid (97-05-2) → 0.5C6H14N2*C7H6O6S

Conditions	Yield
In water	90%

terbium + 5-sulfosalicylic Acid (97-05-2) → terbium(III)(5-sulfosalicylate)3

Conditions	Yield
In acetonitrile at 30℃; Inert atmosphere; Sealed tube; Electrochemical reaction; Sonication;	90%

gadolinium + 5-sulfosalicylic Acid (97-05-2) → gadolinium(III)(5-sulfosalicylate)3

Conditions	Yield
In acetonitrile at 30℃; Inert atmosphere; Sealed tube; Electrochemical reaction; Sonication;	90%

2-amino-3-hydroxypyridine (16867-03-1) + 5-sulfosalicylic Acid (97-05-2) → C5H6N2O*C7H6O6S

Conditions	Yield
In ethanol for 3h; Reflux;	90%

manganese(II) perchlorate hexahydrate + copper(II) 2,3-dioxo-5,6,14,15-dibenzo-1,4,8,12-tetraazacyclopentadeca-7,13-dien (60911-04-8) + water (7732-18-5) + 5-sulfosalicylic Acid (97-05-2) → Mn(III)Mn(II)2(5-sulfosalicylate(3-))2(Cu(II)(2,3-dioxo-5,6,14,15-dibenzo-1,4,8,12-tetraazacyclopentadeca-7,13-diene))2(OH)(H2O)3

Conditions	Yield
With NaOH; air In methanol; water High Pressure; under hydrothermal conditions; mixt. of Mn salt, 5-sulfosalicylic acid, Cu complex, H2O and MeOH stirred at room temp. for 40 min; pH adjusted to 7-8 (1M NaOH); heated at 160°C for 72 h; cooled to room temp. for 36 h; crystals isolated by filtration; washed with H2O; elem. anal.;	89.5%

copper diacetate (142-71-2) + 5-sulfosalicylic Acid (97-05-2) → Cu(2+)*2(O3SC6H3OCOO)Cu(H2O)4(1-)*8H2O = Cu[(O3SC6H3OCOO)Cu(H2O)4]2*8H2O

Conditions	Yield
In N,N-dimethyl-formamide Cu-salt/salicylic acid molar ratio 3:2; refluxing (1 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	89%

nickel diacetate (373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6) + 1,5-diamino-3-azapentane (111-40-0) + 5-sulfosalicylic Acid (97-05-2) → Ni(C4H13N3)(H2O)3(2+)*2(O3SC6H3OCOO)Ni(C4H13N3)(H2O)(1-)*5H2O = [Ni(C4H13N3)(H2O)3][(O3SC6H3OCOO)Ni(C4H13N3)(H2O)]2*5H2O

Conditions	Yield
In N,N-dimethyl-formamide Ni-salt/triamine/salicylic acid molar ratio 3:3:2; refluxing (2.5 h); recrystn. (water), drying (room temp., red. pressure); elem. anal.;	88%

zinc(II) chloride tetrahydrate (29604-34-0) + water (7732-18-5) + 5-sulfosalicylic Acid (97-05-2) → Zn(2+)*2C7H5O6S(1-)*9.1H2O

Conditions	Yield
In tetrahydrofuran at 100℃; for 24h; Sealed tube; High pressure;	88%

2-amino-3-nitropyridine (4214-75-9) + 5-sulfosalicylic Acid (97-05-2) → C5H5N3O2*C7H6O6S

Conditions	Yield
In ethanol for 3h; Reflux;	88%

1,2-bis(1H-benzo[d]imidazol-2-yl)ethane-1,2-diol (3314-32-7) + 5-sulfosalicylic Acid (97-05-2) → C16H14N4O2*2H2O*C7H6O6S

Conditions	Yield
With water In methanol; ethanol at 20℃;	87.51%

H-Gly-NH2 (598-41-4) + 5-sulfosalicylic Acid (97-05-2) → glycinamide 5-sulfosalicylate (1336437-67-2)

Conditions	Yield
In methanol; water	87%

2-amino-4-methyl-3-nitropyridine (6635-86-5) + 5-sulfosalicylic Acid (97-05-2) → C6H7N3O2*C7H6O6S

Conditions	Yield
In ethanol for 3h; Reflux;	87%

3,5-dimethyl-1H-pyrazole (67-51-6) + cadmium(II) acetate dihydrate (5743-04-4) + 5-sulfosalicylic Acid (97-05-2) → Cd(3,5-dimethylpyrazole)2(5-sulfosalicylate)2

Conditions	Yield
In methanol at 20℃; for 2h;	86.4%

pentaphenylantimony (2170-05-0) + 5-sulfosalicylic Acid (97-05-2) → bis(tetraphenylstibonium) sulfosalicylate

Conditions	Yield
In ethanol; toluene byproducts: C6H6; molar ratio Sb-compd./org. sulfonate 2/1; room temp., several min; evapn., recrystn. (ethanol-water, 5:1);	86%

dichloro(phthalocyaninato)zirconium(IV) (59538-92-0) + 5-sulfosalicylic Acid (97-05-2) → phthalocyanine Zr(IV) 5-sulfosalicylic acid (380368-10-5)

Conditions	Yield
In further solvent(s) byproducts: HCl; Zr-compd. suspended in 1-heptanol, 5-sulfosalicylic acid added, heated at 170°C for 8 h; filtered, hexane added, cooled, filtered, washed with excess of hexane, dried in air, dried in vac. at 60°C for 8 h;	86%

Upstream product

• 27279-86-3 2-oxo-2H-chromene-6-sulfonic acid 
• 69089-38-9 2-oxo-2H-chromene-3,6-disulfonic acid 
• 118-55-8 phenyl Salicylate 
• 25149-61-5 5-sulpho-2-hydroxybenzaldehyde 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 83957-15-7 2-hydroxy-5-methoxysulfonylbenzoicacid methyl ester 
• 7446-11-9 sulfur trioxide 
• 69-72-7 salicylic acid 
• 7664-93-9 sulfuric acid 
• 7790-94-5 chlorosulfonic acid 

Downstream Products

• 1708-40-3 2-phenyl-[1,3]dioxan-5-ol 
• 137079-96-0 benzaldehyde-(ethyl-octyl-acetal) 
• 25149-61-5 5-sulpho-2-hydroxybenzaldehyde 
• 1829-32-9 3-Chloro-2-hydroxybenzoic acid 
• 50390-26-6 3-bromo-2-hydroxy-5-sulfobenzoic acid 
• 554-71-2 4-hydroxy-3,5-diiodo-benzenesulfonic acid 
• 34556-95-1 2-methoxy-5-sulfo-benzoic acid 
• 56609-17-7 2-hydroxy-3-nitro-5-sulfo-benzoic acid 
• 17243-13-9 5-chlorosulfonyl-2-hydroxybenzoic acid 
• 69-72-7 salicylic acid 
• 108-95-2 phenol 
• 320-72-9 3,5-dichlorosalicylic acid 
• 118-75-2 chloranil 
• 99152-82-6 3-(4,4'-bis-dimethylamino-benzhydryl)-4-hydroxy-benzenesulfonic acid