97145-59-0

Basic information

• Product Name: 2-amino-4-phenyl-5,6-dihydrobenzoquinazoline
• Synonyms: 2-amino-4-phenyl-5,6-dihydrobenzoquinazoline
• CAS NO: 97145-59-0
• Molecular Weight: 273.337
• Mol File: 97145-59-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-amino-4-phenyl-5,6-dihydrobenzoquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-phenyl-5,6-dihydrobenzoquinazoline(97145-59-0)
• EPA Substance Registry System: 2-amino-4-phenyl-5,6-dihydrobenzoquinazoline(97145-59-0)

Safety Data

• Hazardous Substances Data: 97145-59-0(Hazardous Substances Data)

Upstream product

• 124-46-9 guanidine hydrogen carbonate 
• 100-52-7 benzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 420-04-2 CYANAMID 
• 28353-74-4 3,4-dihydronaphthalen-1(2H)-one O-acetyl oxime 
• 50-01-1 guanidine hydrochloride 
• 6261-32-1 (E)-2-benzylidene-1-tetralone 

Downstream Products

• 97145-82-9 2-Methyl-N-(2-methyl-benzoyl)-N-(4-phenyl-5,6-dihydro-benzo[h]quinazolin-2-yl)-benzamide 
• 97145-81-8 N-Benzoyl-N-(4-phenyl-5,6-dihydro-benzo[h]quinazolin-2-yl)-benzamide 
• 97145-75-0 2-phenylacetylamino-4-phenyl5,6-dihydrobenzoquinazoline 
• 97145-74-9 2-acetylamino-4-phenyl-5,6-dihydrobenzoquinazoline 
• 97145-77-2 2-Methyl-N-(4-phenyl-5,6-dihydro-benzo[h]quinazolin-2-yl)-benzamide 
• 97145-68-1 4-phenylbenzo[h]quinazolin-2-amine 
• 97145-76-1 N-(4-Phenyl-5,6-dihydro-benzo[h]quinazolin-2-yl)-benzamide 

Relevant articles and documents

Copper-catalyzed three-component formal [3 + 1 + 2] annulations for the synthesis of 2-aminopyrimidines fromO-acyl ketoximes

A copper-based catalytic system has been developed to enable formal [3 + 1 + 2] annulations of ketoxime acetates, aldehydes, and cyanamides. This protocol offers a new strategy for the synthesis of highly substituted 2-aminopyrimidine compounds, and more importantly, pyrimidines have now been included in the N-heterocycle family constructed usingO-acyl ketoximes as N-C-C synthons.

The discovery and synthesis of novel adenosine receptor (A2A) antagonists

In high throughput screening of our file compounds, a novel structure 1 was identified as a potent A2A receptor antagonist with no selectivity over the A1 adenosine receptor. The structure-activity relationship investigation using 1 as a template lead to identification of a novel class of compounds as potent and selective antagonists of A2A adenosine receptor. Compound 26 was identified to be the most potent A2A receptor antagonist (Ki = 0.8 nM) with 100-fold selectivity over the A1 adenosine receptor.

SYNTHESIS OF 2-AMINO-4-ARYL-5,6-DIHYDROBENZOQUINAZOLINES AND THEIR DERIVATIVES

Base-catalyzed reactions of 2-arylidene-1-tetralones and guanidine gave 2-amino-4-aryl-5,6-dihydrobenzoquinazolines (IIIa-i), which were oxidized to 2-amino-4-arylbenzoquinazolines (IVa-c). 2-Benzylidene-1-tetralone and alkylguanidines yielded 2-alk