98-03-3 Usage
Description
2-Thenaldehyde, also known as 2-Thenecarboxaldehyde, is an organic compound belonging to the thiophene derivatives family. It is characterized by the presence of a thenyl group attached to a carbonyl group, which gives it unique chemical properties and reactivity.
Uses
Used in Organic Synthesis:
2-Thenaldehyde is used as a versatile building block in the synthesis of various organic compounds, particularly in the introduction of thenyl groups into target molecules. Its reactivity allows for the formation of diverse chemical structures, making it a valuable intermediate in organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Thenaldehyde is used as a key intermediate in the synthesis of β-aryl-β-amino acids and urea derivatives. These compounds are important for the development of new drugs with potential therapeutic applications.
Used as an Arylation Reagent:
2-Thenaldehyde serves as an effective arylation reagent in chemical reactions, facilitating the introduction of aryl groups into various organic substrates. This property is particularly useful in the synthesis of complex organic molecules and pharmaceutical agents.
Used in Antiviral and Cytotoxic Agent Synthesis:
2-Thenaldehyde is also utilized in the synthesis of unsaturated ketones, which have demonstrated antiviral and cytotoxic properties. These agents have potential applications in the development of new antiviral drugs and cancer therapies.
Synthesis Reference(s)
Synthesis, p. 757, 1976 DOI: 10.1055/s-1976-24193Tetrahedron Letters, 36, p. 455, 1995 DOI: 10.1016/0040-4039(94)02284-I
Purification Methods
Wash it with 50% HCl and distil it under reduced pressure just before use. It has UV: 234nm (hexane). The Z-oxime has m 144o, 136-138o and 142o (H2O). [Beilstein
Check Digit Verification of cas no
The CAS Registry Mumber 98-03-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 98-03:
(4*9)+(3*8)+(2*0)+(1*3)=63
63 % 10 = 3
So 98-03-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H4OS/c6-4-5-2-1-3-7-5/h1-4H
98-03-3Relevant articles and documents
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Eichhorn,Trachtenberg
, p. 5183 (1954)
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A “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides
Bartling, Stephan,Beller, Matthias,Chandrashekhar, Vishwas G.,Jagadeesh, Rajenahally V.,Rabeah, Jabor,Rockstroh, Nils,Senthamarai, Thirusangumurugan
supporting information, p. 508 - 531 (2022/02/11)
Functionalized (hetero)aromatic compounds are indispensable chemicals widely used in basic and applied sciences. Among these, especially aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides represent valuable fine and bulk chemicals, which are used in chemical, pharmaceutical, agrochemical, and material industries. For their synthesis, catalytic aerobic oxidation of alcohols constitutes a green, sustainable, and cost-effective process, which should ideally make use of active and selective 3D metals. Here, we report the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcohols in excellent yields in the presence of air.
Characteristic flavor formation of thermally processed N-(1-deoxy-α-D-ribulos-1-yl)-glycine: Decisive role of additional amino acids and promotional effect of glyoxal
Zhan, Huan,Cui, Heping,Yu, Junhe,Hayat, Khizar,Wu, Xian,Zhang, Xiaoming,Ho, Chi-Tang
, (2021/09/28)
The role of amino acids and α-dicarbonyls in the flavor formation of Amadori rearrangement product (ARP) during thermal processing was investigated. Comparisons of the volatile compounds and their concentrations when N-(1-deoxy-α-D-ribulos-1-yl)-glycine r
