98414-56-3 Usage
Description
1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique triazole-containing structure, which contributes to its reactivity and potential applications in medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone is used as a key intermediate in the production of F421000, which is a precursor to Fluconazole. Fluconazole is a widely used antifungal medication effective against a broad range of fungal infections, making this intermediate essential for the development and manufacturing of this important drug.
Check Digit Verification of cas no
The CAS Registry Mumber 98414-56-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,4,1 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 98414-56:
(7*9)+(6*8)+(5*4)+(4*1)+(3*4)+(2*5)+(1*6)=163
163 % 10 = 3
So 98414-56-3 is a valid CAS Registry Number.
98414-56-3Relevant articles and documents
A preparation method of fluconazole
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Paragraph 0046-0054; 0055-0060; 0061-0064; 0069-0074, (2017/08/25)
The invention discloses a preparation method of fluconazol and belongs to the field of pharmaceutical chemistry and chemical synthesis. The preparation method comprises the following reaction processes: adopting low-price and easily-available epoxy chloropropane as a raw material to react with 1,2,4-triazole; then performing oxidation by using sodium hypochlorite; and finally, reacting with a prepared 2,4-difluorophenyl magnesium lithium reagent to prepare fluconazol. The invention provides a brand-new synthetic route and a process, the reaction of each step is easy to operate, the process is simple, the use of a reagent with high toxicity, high environmental protection pressure and high price is effectively avoided, the reaction total yield is improved, the product cost is effectively reduced, and large-scale production can be realized more easily.