98557-59-6

Basic information

• Product Name: N-(3-iodophenyl)-2,2-dichloroacetamide
• Synonyms: N-(3-iodophenyl)-2,2-dichloroacetamide
• CAS NO: 98557-59-6
• Molecular Weight: 329.952
• Mol File: 98557-59-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-iodophenyl)-2,2-dichloroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-iodophenyl)-2,2-dichloroacetamide(98557-59-6)
• EPA Substance Registry System: N-(3-iodophenyl)-2,2-dichloroacetamide(98557-59-6)

Safety Data

• Hazardous Substances Data: 98557-59-6(Hazardous Substances Data)

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 626-01-7 3-Iodoaniline 

Downstream Products

• 1415022-49-9 C₁₅H₁₃Cl₂NO₂ 

Relevant articles and documents

Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: Design, synthesis and biological evaluation

A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC50 > 1000 μM for A549). In this paper, a variety of DCA derivatives were synthesized, and their cytotoxic activities were evaluated. The result showed that the N-phenyl-2,2-dichloroacetamide analogues had satisfactory potencies. Among them, N-(3-iodophenyl)-2,2-dichloroacetamide (3e), an optimized lead compound, has an IC50 against A549 as low as 4.76 μM. Furthermore, it can induce cancer cell apoptosis and has a low toxicity in mice (LD50 = 1117 mg/kg). N-phenyl-2,2-dichloroacetamide analogues has higher cytotoxic activity and N-(3-iodophenyl)-2,2-dichloroacetamide (3e) is an optimized lead compound.