98674-80-7 Usage
Description
(2R,4R)-5,5-DIMETHYL-2-HYDROXY-4-PHENYL-1,3,2-DIOXAPHOSPHORINAN 2-OXIDE is a chiral organophosphorus compound with a unique structure that features a 1,3,2-dioxaphosphorinan ring system. (2R,4R)-5,5-DIMETHYL-2-HYDROXY-4-PHENYL-1,3,2-DIOXAPHOSPHORINAN 2-OXIDE exhibits specific stereochemistry with the 2R,4R configuration, which is crucial for its applications in various chemical processes and reactions.
Uses
Used in Pharmaceutical Industry:
(2R,4R)-5,5-DIMETHYL-2-HYDROXY-4-PHENYL-1,3,2-DIOXAPHOSPHORINAN 2-OXIDE is used as a chiral resolving agent for the resolution of amino acids, amines, and amino alcohols. Its ability to selectively interact with enantiomers is valuable in the synthesis of enantiomerically pure pharmaceutical compounds, which is essential for ensuring the desired biological activity and minimizing potential side effects.
Used in Organic Synthesis:
(2R,4R)-5,5-DIMETHYL-2-HYDROXY-4-PHENYL-1,3,2-DIOXAPHOSPHORINAN 2-OXIDE is used as a reactant in the phosphoalkoxylation of aromatic enones. This reaction is an important method for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and natural products. The use of this chiral compound can lead to the formation of enantiomerically enriched products, which is beneficial for the development of single-enantiomer drugs and other chiral molecules with specific biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 98674-80-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,6,7 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 98674-80:
(7*9)+(6*8)+(5*6)+(4*7)+(3*4)+(2*8)+(1*0)=197
197 % 10 = 7
So 98674-80-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15O4P/c1-11(2)8-14-16(12,13)15-10(11)9-6-4-3-5-7-9/h3-7,10H,8H2,1-2H3,(H,12,13)/t10-/m1/s1
98674-80-7Relevant articles and documents
A method for preparing chiral ring phosphoric acid (by machine translation)
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Paragraph 0050, (2017/03/18)
The invention discloses a method for preparing chiral ring of phosphoric acid, the method comprises the following steps: a Isobutyraldehyde, aromatic aldehyde under the condition of chiral catalyst to catalyze the reaction generating chiral 3-aryl-3-hydroxy -2,2-dimethyl-propionaldehyde; chiral b 3-aryl-3-hydroxy -2,2-dimethyl propionic aldehyde reduction to obtain chiral 1-aryl -2,2-dimethyl -1,3-propylene glycol; c in methylene chloride under the conditions of reaction with phosphorus oxychloride to obtain chiral 4-aryl-2-chloro -5,5-dimethyl-2-oxo -1, 3, 2-dioxo-phosphorus heterocycle hexane chloride; in d hydrolysis under alkaline conditions, dyeworks generating chiral ring phosphoric acid. The high optical purity of the target product, the operation is simple, low cost, high yield, less pollution, belonging to the field of organic synthesis. (by machine translation)
The Design of Resolving Agents. Chiral Cyclic Phosphoric Acids
Hoeve, Wolter ten,Wynberg, Hans
, p. 4508 - 4514 (2007/10/02)
A systematic investigation has been started with the twofold purpose of synthesizing efficient resolving agents and of gaining an insight into the factors that contribute to successful resolutions.We report on the synthesis, resolution, and application of a number of chiral cyclic phosphoric acids.Among these acids, 4-(2-chlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide (7A) is an efficient resolving agent, being useful for the resolution of amines and amino acids.Acid chloride 20 is a useful reagent for the determination of the ee of chiral amines.The absolute configuration of (-)-7A was determined through an X-ray structure determination of its salt with (-)-(p-hydroxyphenyl)glycine.