99-26-3

Basic information

• Product Name: BISMUTH SUBGALLATE
• Synonyms: 2-benzodioxabismole-5-carboxylicacid,2,7-dihydroxy-3;basicbismuthgallate;bismuthgattatlba-sic;Bismuthoxygallate;Bismuthsubgarate;Callicacidbismuthbasicsalt;BISMUTH GALLATE;BISMUTH GALLATE, BASIC
• CAS NO: 99-26-3
• Molecular Formula: C7H5BiO6
• Molecular Weight: 394.09
• EINECS: 202-742-2
• Product Categories: Organometallics;Bismuth;Catalysis and Inorganic Chemistry;Chemical Synthesis;Herb extract;API
• Mol File: 99-26-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 223 °C (dec.)(lit.)
• Boiling Point: 501.1oC at 760mmHg
• Flash Point: 270.9oC
• Appearance: white to yellow crystals
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Practically insoluble in water and in ethanol (96 per cent). It dissolves in mineral acids with decomposition and in solutions of alkali hydroxides, producing a reddishbrown liquid.
• Stability: Stable, but may be light sensitive.
• Merck: 14,1283
• CAS DataBase Reference: BISMUTH SUBGALLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BISMUTH SUBGALLATE(99-26-3)
• EPA Substance Registry System: BISMUTH SUBGALLATE(99-26-3)

Safety Data

• Statements: 20/21/22
• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 99-26-3(Hazardous Substances Data)

Usage

Description

Bismuth Subgallate is a chemical compound that has pharmacological activity and is used in the treatment of Helicobacter pylori infections and as a pharmaceutical abuse deterrent compound.

Uses

Used in Pharmaceutical Industry:
Bismuth Subgallate is used as a pharmaceutical abuse deterrent compound for its ability to discourage misuse and abuse of medications.
Used in Medical Treatment:
Bismuth Subgallate is used as a treatment for Helicobacter pylori infections, which are a common cause of stomach ulcers and other gastrointestinal issues. It helps to reduce the production of NO and PGE2 by macrophages, which are involved in the inflammatory response to the infection.
Investigations of Pharmacological Activity:
Research has been conducted on the pharmacological activity of Bismuth Subgallate, specifically its ability to inhibit the production of NO and PGE2 by macrophages. This suggests that it may have potential applications in the treatment of various inflammatory conditions.

InChI:InChI=1/C7H6O5.Bi.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;;/h1-2,8-10H,(H,11,12);;1H2/q;+3;/p-3/rC7H5BiO6/c9-4-1-3(7(10)11)2-5-6(4)14-8(12)13-5/h1-2,9,12H,(H,10,11)

Synthetic route

bismuth(III) nitrate + 3,4,5-trihydroxybenzoic acid (149-91-7) + water (7732-18-5) → dermatol (99-26-3)

Conditions	Yield
at 60 - 80℃; for 0.333333h;

Upstream product

• 46140-16-3 bismuth(III) nitrate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 7732-18-5 water 

Relevant articles and documents

Preparation method of bismuth subgallate

The invention provides a preparation method of bismuth subgallate, comprising the following steps: Step (1), adding bismuth trioxide into concentrated nitric acid to dissolve bismuth trioxide, and then adding deionized water to obtain a bismuth nitrate solution; Step (2) adding deionized water into gallic acid to dissolve gallic acid so as to obtain a gallic acid aqueous solution; Step (3), adding the gallic acid aqueous solution into the bismuth nitrate solution at the molar ratio of gallic acid in the gallic acid aqueous solution to bismuth nitrate in the bismuth nitrate solution being 1.1:1-1.2:1, so as to obtain a yellow precipitate; and Step (4) filtering the yellow precipitate to obtain a filter cake, washing the filter cake with deionized water and finally drying so as to obtain bismuth subgallate. The preparation method of bismuth subgallate is simple to operate and is cost-saving.