99-43-4 Usage
Description
Oxybuprocaine is a benzoate ester local anesthetic, specifically an ester-based "caine" compound, formed by the combination of 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol. It is particularly utilized in the fields of ophthalmology and otolaryngology due to its fast onset and short duration of action.
Used in Ophthalmology:
Oxybuprocaine is used as a topical anesthetic for ocular procedures, providing rapid and effective pain relief during diagnostic and surgical interventions. Its quick onset and short duration make it an ideal choice for minimizing discomfort and ensuring patient cooperation during eye examinations and minor surgeries.
Used in Otolaryngology:
In the field of otolaryngology, Oxybuprocaine is used as a local anesthetic for procedures involving the ear, nose, and throat. Its fast-acting properties allow for swift pain relief and numbness, facilitating a comfortable experience for patients undergoing various diagnostic and therapeutic interventions in this specialty.
Used in Pharmaceutical Industry:
Oxybuprocaine is also utilized in the pharmaceutical industry for the development of anesthetic formulations. Its ester-based structure and local anesthetic properties make it a valuable component in the creation of medications designed to provide pain relief and numbness for specific medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 99-43-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99-43:
(4*9)+(3*9)+(2*4)+(1*3)=74
74 % 10 = 4
So 99-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3
99-43-4Relevant articles and documents
Synthetic method of oxybuprocaine hydrochloride
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Paragraph 0019; 0067; 0076-0079; 0084; 0089-0090, (2021/07/31)
The synthetic method comprises the following steps: (1) carrying out etherification reaction on a compound as shown in a formula II and 1-bromobutane to prepare a compound as shown in a formula III; (2) carrying out transesterification on the compound as shown in the formula III and 2-(diethylamino) ethanol under the action of a catalyst, and salifying to prepare a compound as shown in a formula IV; (3) carrying out reduction reaction on the compound as shown in the formula IV and a reducing agent to obtain oxybuprocaine free alkali as shown in a formula V; and (4) carrying out salt forming reaction and devitrification on the oxybuprocaine free alkali as shown in the formula V to obtain the oxybuprocaine hydrochloride as shown in the formula I. The invention further discloses a preparation method of the oxybuprocaine hydrochloride. According to the synthetic method of the oxybuprocaine hydrochloride, the synthetic route step length is proper, the three-step reaction and one-step salification are realized, the high-temperature and high-pressure reaction is avoided, the requirement on equipment is not high, and the synthetic method is suitable for industrial production.
