99-90-1 Usage
Description
4'-Bromoacetophenone is an organic compound that serves as a crucial intermediate in the synthesis of various organic compounds. It is characterized by the presence of a bromine atom attached to a benzene ring, with an acetophenone group attached to the same ring. This unique structure makes it a versatile building block in the production of a wide range of products.
Uses
Used in Pharmaceutical Industry:
4'-Bromoacetophenone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Pesticide Industry:
In the pesticide industry, 4'-Bromoacetophenone is utilized as an essential component in the production of various agrochemicals. Its ability to form stable compounds makes it suitable for use in creating effective and long-lasting pesticides.
Used in Dye Industry:
4'-Bromoacetophenone is employed as a vital intermediate in the synthesis of dyes. Its chemical properties enable the creation of dyes with specific color characteristics and stability, making it an important component in the dye manufacturing process.
Used in Flavors and Fragrances Industry:
In the flavors and fragrances industry, 4'-Bromoacetophenone is used as a starting material for the synthesis of various aromatic compounds. Its unique structure allows for the development of new fragrances and flavorings with distinct scents and tastes.
Used in Perfume Industry:
4'-Bromoacetophenone is utilized as a fundamental component in the production of perfumes. Its ability to form stable and aromatic compounds makes it an essential ingredient in creating long-lasting and unique perfumes.
Used in Liquid Crystals Industry:
In the liquid crystals industry, 4'-Bromoacetophenone is used as an intermediate for the synthesis of liquid crystal compounds. Its unique structure contributes to the development of advanced liquid crystal materials with specific properties, such as improved stability and response time.
Used in Photobiology Research:
Labeled 4'-Bromoacetophenone possesses activity against positive phototaxis of Chlamydomonas cells, making it a valuable tool in photobiology research. Its ability to influence the behavior of these cells provides insights into the underlying mechanisms of phototaxis and can potentially lead to new applications in various fields.
Preparation
4'-Bromoacetophenone is synthesized by the reaction of bromobenzene and acetic anhydride in the presence of aluminum trichloride. Add bromobenzene and dry carbon disulfide into the reactor, put in powdered anhydrous aluminum trichloride, heat until it starts to reflux, stop heating, add acetic anhydride dropwise, and then reflux for 1 hour after adding, steam out carbon disulfide, and put it while it is still hot. The reactant was poured into the hydrochloric acid ice-water mixture, filtered to dryness, and distilled under reduced pressure to obtain p-bromoacetophenone.
Synthesis Reference(s)
The Journal of Organic Chemistry, 51, p. 5400, 1986 DOI: 10.1021/jo00376a064Tetrahedron Letters, 26, p. 4657, 1985 DOI: 10.1016/S0040-4039(00)98778-1
Purification Methods
Crystallise it from EtOH, MeOH or from pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 647.]
Check Digit Verification of cas no
The CAS Registry Mumber 99-90-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 99-90:
(4*9)+(3*9)+(2*9)+(1*0)=81
81 % 10 = 1
So 99-90-1 is a valid CAS Registry Number.
99-90-1Relevant articles and documents
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Bothner-By
, p. 3293,3294 (1955)
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Visible light-mediated, high-efficiency oxidation of benzyl to acetophenone catalyzed by fluorescein
Geng, Haoxing,Liu, Xin,Zhu, Qing
supporting information, (2021/12/20)
An environmentally friendly aerobic oxidation of benzyl C(sp3)-H bonds to ketones via selective oxidation catalysis was developed. Fluorescein is an efficient photocatalyst with excellent chemical selectivity. The reaction has a wide substrate scope, and a successful gram-scale experiment demonstrated its potential industrial utility.
One-Dimensional Organic Conjugated Polymers as Recyclable Heterogeneous Photocatalysts
Lei, Zhexuan,Liu, Yiming,Ma, Yuguo,Mo, Yitian,Tong, Yujie
supporting information, (2022/03/18)
Organic conjugated polymers with long-range conjugation generally have strong light absorption capacity in the visible light region and impressive performance in charge transfer, which endows them great application potential in the field of opto-electronic materials. However, there are few reports on their use in photocatalytic reactions. At present, it has been reported that a variety of donor-acceptor (D?A) type organic dyes can be used in efficient organic photocatalytic transformations. We designed and synthesized one-dimensional organic conjugated polymers pPhCzBP-Th and pPhCzBP-DTh with D?A structure, and proved that they are good heterogeneous photo-redox catalysts, which can photocatalyze hydrodehalogenation reduction of α-bromoacetophenone and its derivatives. Due to the strong reducibility of the excited state, pPhCzBP-Th can also efficiently reduce α-chloroacetophenone. Furthermore, by simply wrapping the catalyst powder, high-efficient separation of products and catalysts recycling can be achieved.