99050-36-9

Basic information

• Product Name: 3-(3,5-dimethoxyphenyl) propionic acid chloride
• Synonyms: 3-(3,5-dimethoxyphenyl) propionic acid chloride
• CAS NO: 99050-36-9
• Molecular Weight: 228.675
• Mol File: 99050-36-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3,5-dimethoxyphenyl) propionic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-dimethoxyphenyl) propionic acid chloride(99050-36-9)
• EPA Substance Registry System: 3-(3,5-dimethoxyphenyl) propionic acid chloride(99050-36-9)

Safety Data

• Hazardous Substances Data: 99050-36-9(Hazardous Substances Data)

Upstream product

• 16909-11-8 3-(3,5-dimethoxyphenyl)acrylic acid 
• 20767-04-8 (E)-3,5-dimethoxycinnamic acid 
• 7311-34-4 3,5-dimethoxybenzaldehdye 

Downstream Products

• 1035270-39-3 rel-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide 
• 1000895-54-4 5-(3,5-dimethoxyphenyl)-3-oxopentanenitrile 
• 1000895-53-3 5-[2-(3,5-dimethoxy-phenyl)-ethyl]-1H-pyrazol-3-ylamine 
• 99050-45-0 8-Benzyloxy-6-methoxy-1-oxo-2-(3-oxo-butyl)-1,2,3,4-tetrahydro-naphthalene-2-carbaldehyde 
• 99050-46-1 5-Benzyloxy-7-methoxy-1,9,10,10a-tetrahydro-2H-phenanthren-3-one 
• 99050-47-2 8-Benzyloxy-6-methoxy-2-(3-oxo-butyl)-3,4-dihydro-2H-naphthalen-1-one 
• 99050-48-3 5-Benzyloxy-7-methoxy-9,10-dihydro-phenanthren-3-ol 
• 99050-40-5 2-Benzenesulfinyl-6,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one 
• 99050-49-4 5-Benzyloxy-7-methoxy-phenanthren-3-ol 
• 99050-44-9 3,4-Dihydro-2-(hydroxymethylene)-6-methoxy-8-(phenylmethoxy)-1(2H)-naphthalenone 
• 99050-39-2 6,8-Dimethoxy-2-phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one 
• 99050-43-8 8-Benzyloxy-6-methoxytetralone 
• 99050-38-1 4-(3,5-Dimethoxyphenyl)butyric acid methyl ester 
• 91555-31-6 4-(3,5-dimethoxyphenyl)butanoic acid 

Relevant articles and documents

New and convergent synthesis of AZD 4547

A practical and convergent synthetic route of AZD 4547 was developed successfully. The intermediate 5-(3,5-dimethoxyphenylethyl)-1H-pyrazol-3-amine (7) was prepared from 3,5-dimethoxybenzaldehyde through 6 simple steps in 52.3% yield. Another intermediate 4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzoic acid (14) was synthesized from ethyl 4-fluorobenzoate and (2R,6S)-2,6-dimethylpiperazine in 62% yield over 2 steps. Finally, AZD 4547 was obtained from 7 and 14 in 73% yield and 99.1% purity. Purification methods of the intermediates and the final product involved in the route were developed.