99887-44-2Relevant articles and documents
DRUG DELIVERY SYSTEM INCLUDING DRUG-LOADED PHOSPHATE MICELLE
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Paragraph 0035; 0043-0047, (2019/12/25)
The present invention relates to a drug carrier comprising a drug and a carrier loaded with the drug, wherein the carrier is a micelle composed of a phosphate surfactant. The micelle, consisting of the phosphate surfactant contained in a drug carrier, can selectively release the drug loaded into the micelle by being cleaved by an overexpressed enzyme around a target, thereby significantly reducing drug side effects in vivo compared to the prior art, while maximizing a therapeutic effect.COPYRIGHT KIPO 2020
DIOLIC PHOSPHOLIPIDS. IV. NEW SYNTHESIS OF DIOLIC PHOSPHATIDIC ACIDS
Nifant'ev, E. E.,Predvoditelev, D. A.,Rasadkina, E. N.,Kozlova, G. G.
, p. 424 - 427 (2007/10/02)
A new method for the synthesis of diolic phosphatidic acids is proposed that is based on the alkylation of potassium salts of higher carboxylic acids by cyclic alkylene phosphates. The initial compounds for the phospholipid synthesis, namely neutral alkylene phosphates and amidophosphates, are prepared by the Todd-Atherton oxidative phosphorylation of morpholine and trichloroethanol by ethylene and trimethylene phosphates.