China (Mainland)
Baclofen CAS NO.1134-47-0
- Min.Order: 1 Metric Ton
- Payment Terms: T/T,
- Product Details
Keywords
- Baclofen
- 1134-47-0
Quick Details
- ProName: Baclofen
- CasNo: 1134-47-0
- Appearance: white powder
- DeliveryTime: 3 days after payment
- PackAge: 25kg/plastic drum,200Kg/iron drum
- Port: Shanghai, Shenzhen, Guangzhou, Hongkon...
- ProductionCapacity: 1 Metric Ton/Day
- Purity: 99%
- Storage: Keep in cool and dry place, away from ...
- LimitNum: 1 Metric Ton
- Related Substances: <0.1%
- Residue on Ignition: <0.1%
- Heavy Metal: <0.002%
- Valid Period: 2 years
Superiority
- 【Density】
- 1.285 g/cm3
- 【Melting Point】
- 208-210ºC
- 【Boiling Point】
- 364.3ºC at 760 mmHg
- 【Vapour】
- 6.01E-06mmHg at 25°C
- 【Refractive Index】
- 1.576
- 【Flash Point】
- 174.1ºC
- 【Water】
- 1 M HCl: 50 mg/mL
- 【Solubilities】
- 1 M HCl: 50 mg/mL
- 【Color/Form】
- white to very faintly yellow
- 【Stability】
- No data.
- 【Storage temp】
- 2-8°C
- 【Computed Properties】
-
Molecular Weight:213.66078 [g/mol]
Molecular Formula:C10H12ClNO2
XLogP3:-1
H-Bond Donor:2
H-Bond Acceptor:3
Rotatable Bond Count:4
Exact Mass:213.055656
MonoIsotopic Mass:213.055656
Topological Polar Surface Area:63.3
Heavy Atom Count:14
Formal Charge:0
Complexity:191
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:1
Feature 3D Anion Count:1
Feature 3D Cation Count:1
Feature 3D Ring Count:1
Effective Rotor Count:4
Conformer Sampling RMSD:0.6
CID Conformer Count:21
Details
-
Safety and Handling
- 【Hazard Codes】
- T:Toxic;
- 【Risk Statements】
- R61;R25;R36/37/38;R42/43
- 【Safety Statements 】
- S52;S22;S36/37/39;S45
- 【HazardClass】
- 6.1(b)
- 【Safety】
-
Poison by ingestion, subcutaneous and intravenous routes. Human systemic effects by ingestion: blood pressure lowering, coma, muscle weakness, pulse rate decrease, respiratory depression. When heated to decomposition it emits toxic fumes of Cl− and NOx. A muscle relaxant.
Safety Information of Baclofen (CAS NO.1134-47-0)
Hazard Codes:T,
Risk Statements: 61-25-36/37/38-42/43-20/21/22
R61:May cause harm to the unborn child.
R25 :Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-22-36/37/39-45-52-26
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S52:Not recommended for interior use on large surface areas.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MW5084200
HazardClass: 6.1(b)
PackingGroup: III - 【PackingGroup 】
- III
- 【Transport】
- UN 2811
Use and Manufacturing
- 【Usage】
- Specific GABA-B receptor agonist. Muscle relaxant (skeletal)
Biomedical Effects and Toxicity
- 【Biological Activity】
- Selective GABA B receptor agonist. Skeletal muscle relaxant.
- 【Pharmacological Action】
-
- Endogenous compounds and drugs that bind to and activate GABA-B RECEPTORS.
- A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)