SHINING HEALTH GROUP LIMITED

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SHINING HEALTH GROUP LIMITED

Country:China (Mainland)

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hot sell High quality Ibuprofen

hot sell High quality Ibuprofen CAS NO.15687-27-1

  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,T/T
  • Product Details

Keywords

  • best price Ibuprofen .
  • 99% purity Ibuprofen.
  • hot sell Ibuprofen.

Quick Details

  • ProName: hot sell High quality Ibuprofen
  • CasNo: 15687-27-1
  • Molecular Formula: C4H12ClN5
  • Appearance: White odorless crystalline powder
  • Application: Ibuprofen is used primarily for fever,...
  • DeliveryTime: within one week
  • PackAge: packing 25kg/drum
  • Port: Any prot in china
  • ProductionCapacity: 10000 Kilogram/Month
  • Purity: 99%
  • Transportation: by air/sea/courier
  • LimitNum: 1 Kilogram
  • Valid Period: 2 years

Superiority

 

Our advantages:

 

1.Specialized manufacturer and trader of Pharmaceutical materials, Food additives, Health care products,and cosmatic materials.

2.A series of products with self-IPRs, including CMC for ceramic purpose, Hydroxypropyl starch ether, printing grade phosphate starch and acetate starch. 

3.Closely cooperative relationships with business partners and obtained big support from them. 

4.As the agent of over 200 kinds of chemical materials, with complete product structures. 

 

Best Service:

 

1.Sticking to such policy of "quality first, customer first".

2.Honest business as number one priority, and work for meeting your demands. 

3.With the newest quality, and best service.

5.The most strict management system in this field.

6.Free sample.

Details

 

Pharmacology
Indication For symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.
Pharmacodynamics Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, which are thought to act through inhibition of prostaglandin synthesis.
Mechanism of action The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.
Absorption ~ 80% absorbed from GI tract

Time to reach peak plasma concentration = 47 minutes (suspension), 62 minutes (chewable tablets), 120 minutes (conventional tablets)

Volume of distribution Not Available
Protein binding 90-99% to whole human plasma and site II of purified albumin, binding appears to be saturable and becomes non-linear at concentrations exceeding 20 mcg/ml.
Metabolism R-enanatiomer undergoes extensive enantiomeric conversion (53-65%) to the more active S-enantiomer in vivo. Metablized by oxidation to 2 inactive metabolites: (+)-2[4´-(2-hydroxy-2-methylpropyl)phenyl]propionic acid and (+)-2-[4´-(2-carboxypropyl)phenyl]propionic acid. Very small amounts of 1-hydroxyibuprofen and 3-hydroxyibuprofen have been recovered from urine. Cytochrome P450 2C9 is the major catalyst in the formation of oxidative metabolites. Oxidative metabolites may be conjugated to glucuronide prior to excretion.
Route of elimination Ibuprofen is rapidly metabolized and eliminated in the urine.
Half life 2-4 hours
Clearance Not Available
Toxicity

Side effects: May cause peripheral edema and fluid retention. Use caution in patients with congestive heart failure or severe uncontrolled hypertension. May cause dyspepsia, heartburn, nausea, vomiting, anorexia, diarrhea, constipation, stomatitis, flatulence, bloating, epigastric pain, and abdominal pain. Peptic ulcer and GI bleeding have been reported. May also cause dizziness, headache and nervousness. Acute renal failure accompanied by acute tubular necrosis has been reported.

Most common symptoms of overdose are abdominal pain, nausea, vomiting, lethargy, vertigo, drowsiness (somnolence), dizziness and insomnia. Other symptoms of overdose include headache, loss of consciousness, tinnitus, CNS depression, convulsions and seizures. May rarely cause metabolic acidosis, abnormal hepatic function, hyperkalemia, renal failure, dyspnea, respiratory depression, coma, acute renal failure, and apnea (primarily in very young pediatric patients).

LD50=1255mg/kg(orally in mice)

Affected organisms
  • Humans and other mammals
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Other products of this supplier

SHINING HEALTH GROUP LIMITEDTel:USA:563-513-3839 Fax:0311-67695628  Email:info@pharm-world.com
 Address:No.121TANGU EAST STREET,SHIJIAZHAUNG,CHINA,050000