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Cyclosporin A CAS NO.59865-13-3
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,MoneyGram,Other
- Product Details
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- Cyclosporin A price
- Cyclosporin A CAS 59865-13-3
- Cyclosporin A supplier in China
Quick Details
- ProName: Cyclosporin A
- CasNo: 59865-13-3
- Molecular Formula: C62H111N11O12
- Appearance: white powder
- Application: Cyclosporin A is a hydrophobic cyclic ...
- DeliveryTime: 15 days after order confirmed
- PackAge: 25kg/bucket or as per your request
- Port: Shanghai, Ningbo, Tianjin, etc
- ProductionCapacity: 1 Metric Ton/Month
- Purity: 99%
- Storage: Stored in cool, dry and ventilation pl...
- Transportation: by courier door to door or by sea
- LimitNum: 1 Kilogram
Superiority
Superior quality, moderate price & quick delivery.
Details
| Cyclosporin A Chemical Properties |
| mp | 148-151°C |
| storage temp. | 2-8°C |
| solubility | ethanol: 30 mg/mL |
| form | solid |
| color | white |
| Merck | 13,2781 |
| CAS DataBase Reference | 59865-13-3(CAS DataBase Reference) |
| EPA Substance Registry System | Cyclosporin A(59865-13-3) |
| Safety Information |
| Hazard Codes | T,Xn |
| Risk Statements | 45-60-22-40 |
| Safety Statements | 53-45-36/37-24/25-22 |
| WGK Germany | 3 |
| RTECS | GZ4120000 |
| Hazardous Substances Data | 59865-13-3(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| Cyclosporin A | English |
| SigmaAldrich | English |
| Cyclosporin A Usage And Synthesis |
| Chemical Properties | White Powder |
| Usage | prothrombogenic agent |
| Usage | Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. |
| Usage | An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. |
| General Description | White prismatic needles (from acetone) or white powder. |
| Air & Water Reactions | Slightly water soluble . |
| Reactivity Profile | Cyclosporin A is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
| Health Hazard | SYMPTOMS: Symptoms of exposure to Cyclosporin A include hepatotoxicity, nephrotoxicity, hyperkalemia, hyperuricemia, convulsions, renal dysfunction, tremor, hirsutism, hypertension, gum hyperplasia, cramps, acne, headache, diarrhea, nausea, vomiting, abdominal discomfort, paresthesia, flushing, leukopenia, lymphoma, sinusitis and gynecomastia. In 2% or less of persons exposed, it has caused allergic reactions, anemia, anorexia, confusion, conjunctivitis, edema, fever, brittle fingernails, gastritis, hearing loss, hiccups, hyperglycemia, muscle pain, peptic ulcer, thrombocytopenia and tinnitus. Rare reactions include anxiety, chest pain, constipation, depression, hair breaking hematuria, joint pain, lethargy, mouth sores, myocardial infarction, night sweats, pancreatitis, pruritus, swallowing difficulty, tingling, upper gastrointestinal bleeding, visual disturbance, weakness and weight loss. It has caused kidney and liver damage. An increased susceptibility to infection may occur. Other symptoms include gastrointestinal disturbance, rashes and angioedema. |
| Fire Hazard | Flash point data for Cyclosporin A are not available; however, Cyclosporin A is probably combustible. |