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Home > Products >  Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-

Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)- CAS NO.362-07-2

  • Min.Order: 10 Kilogram
  • Payment Terms: L/C,T/T,MoneyGram,Other
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Keywords

  • Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? price
  • Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? CA 362-07-2
  • Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? supplier in China

Quick Details

  • ProName: Estra-1,3,5(10)-triene-3,17-diol,2-met...
  • CasNo: 362-07-2
  • Molecular Formula: C19H26O3?
  • Appearance: off-white soild
  • Application: Used for Pesticide intermediates A n...
  • DeliveryTime: 15 days after order confirmed
  • PackAge: 1kg/bag, 1kg/drum or 25kg/drum or as p...
  • Port: Shanghai, Ningbo, Tianjin, etc
  • ProductionCapacity: 1 Metric Ton/Month
  • Purity: 99%
  • Storage: Stored in cool, dry and ventilation pl...
  • Transportation: as per your request
  • LimitNum: 10 Kilogram

Superiority

superior quality

Details

2-METHOXYESTRADIOL Chemical Properties
mp  188-190°C
storage temp.  −20°C
solubility  DMSO: 10 mg/mL
form  crystalline
color  light yellow
CAS DataBase Reference 362-07-2(CAS DataBase Reference)
 
Safety Information
Hazard Codes  T,Xi
Risk Statements  23/24/25-36/37/38-48-61-60-46-45
Safety Statements  22-26-36/37/39-45-53-36
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  KG7537500
MSDS Information
Provider Language
SigmaAldrich English
 
2-METHOXYESTRADIOL Usage And Synthesis
Chemical Properties Off-White Solid
Usage A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
Usage A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
Usage 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Usage 2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Usage 2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Biological Activity Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

 

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