We supply Afatinib with high purity and competitive price.

This is Xiang from Holypharm biotech co., ltd, we are pharmaceutical corporation with complete industry chain of research, development, production and marketing.As for some projects we also can provide technical support.

We supply API for many high-end market with high quality and competitive price, as well as co-operating with MSDand Merck CO., LTD. 

Afatinib is a tyrosine kinase inhibitor which is a 4-anilinoquinazoline. It is prepared has the dimaleate salt. FDA approved on July 12, 2013.                                                

Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signalling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumour growth was inhibited.