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D-(+)-Mandelic acid industry

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    1. The uses of D-(+)-Mandelic acid

     

     

    The D-(+)-Mandelic acid is mainly used in the medical community as an antibacterial, particularly in the treatment of urinary tract infections. It has also been used as an oral antibiotic. In skin care, it is also an alternative to glycolic acid in skin care products. With it is widely used in many pharmaceutical industry, the demand of D-(+)-Mandelic acid is gradually increasing.

     

    2. D-(+)-Mandelic acid industry

     

     

    D-(+)-Mandelic acid was discovered while heating amygdalin, an extract of bitter almonds, with diluted hydrochloric acid. The name is derived from the German "Mandel" for "almond". Derivatives of mandelic acid are formed as a result of metabolism of adrenaline and noradrenaline by monoamine oxidase and catechol-O-methyl transferase.

    Now D-(+)-Mandelic acid is usually prepared by the acid-catalysed hydrolysis of mandelonitrile, which is the cyanohydrin of benzaldehyde. Mandelonitrile can also be prepared by reacting benzaldehyde with sodium bisulfite to give the corresponding adduct, forming mandelonitrile with sodium cyanide, which is hydrolyzed.

     




     

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