Pazopanib
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1. The description of Pazopanib (Votrient)
Pazopanib (CAS No. 444731-52-6) is a tyrosine kinase inhibitor (TKI), a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Votrient is the trade name of Pazopanib. With the chemical name GW 786034, 5-[[4-[(2,3-dimethyl-2H-indazol-6- yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide monohydrochloride, it has the molecular formula C21H23N7O2S•HCl and a molecular weight of 473.99.
Molecular Structure:
2. The basic properties of Pazopanib
Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.
HANGZHOU HOLYPHARM BIOTECH CO.,LTD, a professional supplier of active pharmaceutical ingredients and intermediates, agrochemicals and Veterinary products gave the inactive ingredients of VOTRIENT: Tablet Core: Magnesium stearate, povidone, microcrystalline cellulose, sodium starch glycolate. Coating: Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol 400 (PEG 400), titanium dioxide, polysorbate 80.
3. The uses of Pazopanib
Votrient (pazopanib) has been approved by the FDA for the treatment of soft tissue sarcoma in patients who have already received chemotherapy. It is suitable for the treatment of advanced renal cell carcinoma (a kind of renal tubule cells found in the kidney type), soft tissue sarcoma (STS), the epithelium of ovarian cancer and non-small cell lung cancer (NSCLC). So far, Pazopanib Trial is very good.
Verified Supplier
HANGZHOU HOLYPHARM BIOTECH CO.,LTD
- Country: China (Mainland)
- Year Established: 2009
- Business License:
- Business type: Other
- Integral:
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