A material data safety sheet (MSDS) is an important component of product stewardship and workplace safety.

The following detailed information of material data safety sheet free(MSDS) are provided by HANGZHOU HOLYPHARM BIOTECH CO.,LTD, a professional supplier of active pharmaceutical ingredients and intermediates, agrochemicals and Veterinary products.

1. Identification of substance:
Trade name: Pazopanib

2. Composition/data on components:
Chemical Name: Pazopanib
Synonyms: GW786034
Hazardous Ingredient: Pazopanib
CAS Registry Number: 635702-64-6
Molecular Weight: 473.98
Molecular Formula: C₂₁H₂₃N₇O₂S.HCl

3. Hazards identification:
Hazard Description:
Toxic. Contains a pharmaceutically active ingredient.
Handling should only be performed by personnel trained and familiar
with handling of potent active pharmaceutical ingredients
Moderate to severe irritant to the skin and eyes

4. First aid measures:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. Fire fighting measures:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: emits toxic fumes such as carbon monoxide, etc.

6. Accidental release measures:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting:absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. Handling and storage:
Information for safe handling: avoid inhalation and contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20°C

8. Exposure controls and personal protection:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. Physical and chemical properties:
Solubility in / Miscibility with water: ≥95
Solvent content:none

10. Stability and reactivity:
Stability:stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided:protect from light and heat
Dangerous products of decomposition:thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. Toxicological information:
RTECS#:
Acute toxicity: none known
Primary irritant effect:not known
On the skin:none known
On the eye:not known; may be an irritant

12. Ecological information:
General notes: no data available

13. Disposal consideration:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. Transport information:
DOT:
Proper shipping name: none
Non-Hazardous for transport:this substance is considered to be non-hazardous for transport

IATA class:
Proper shipping name: none
Non-Hazardous for transport:this substance is considered to be non-hazardous for transport

15. Regulations:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:

S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear protective clothing, gloves and eye/face protection
R28: Very toxic if swallowed
R38: Irritating to skin
R41: Risk of serious damages to eyes
R48: Toxic; danger of serious damage to health by prolonged exposure
R62: Possible risk of impaired fertility
R63: Possible risk of harm to unborn child

16. Other information:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user.