Posaconazole
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1. The description of Posaconazole
Posaconazole (CAS No. 171228-49-2) is an antifungal medication that fights certain infections caused by fungus. 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one are its synonyms. With a Brand Names Noxafil, it has has the molecular formula C37H42F2N8O4 and molecular weight of 700.78. Posaconazole is a white powder and is insoluble in water.
Molecular Structure :
2. The uses of Posaconazole
Posaconazole ( Noxafil ) is used to prevent serious fungal infections in people with a weakened ability to fight infection. Posaconazol is also used to treat yeast infections of the mouth and throat including yeast infections that could not be treated successfully with other medications. Posaconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection. HANGZHOU HOLYPHARM BIOTECH CO.,LTD, a professional supplier of active pharmaceutical ingredients and intermediates, agrochemicals and Veterinary products, said that Noxafil may also be used for other purposes not listed.
3. Mode of action of Posaconazole
Posaconazole ( Noxafil ) works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as ATPase and enzymes of the electron transport system, thus inhibiting growth of the fungi. It does this by blocking the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase
and accumulation of methylated sterol precursors. Posaconazole is significantly more potent at inhibiting
14-alpha demethylase than itraconazole.
Verified Supplier
HANGZHOU HOLYPHARM BIOTECH CO.,LTD
- Country: China (Mainland)
- Year Established: 2009
- Business License:
- Business type: Other
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