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titanium dioxide toxicity
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Titanium dioxide (CAS No. 13463-67-7) is considered to be one safe, inert and non-toxic substance chemical, as we could find much authoritative statements in MSDS (Material Safety Data Sheets). And in its description of "Health damage", there will be no changes for lungs in case of long-term breath. Information on inhalation toxicity in man is sparse, and lung changes have been recorded in a number of individuals. Besides, the ACGIH states that titanium dioxide is "not classifiable as a human carcinogen". Therefore, it is reasonable to conclude that titanium dioxide, for not being a kind of cancer-causing substance, is generally safe for use in foods, drugs, paints and cosmetics.
The titanium dioxide toxicity are as below: (The information are provided by Shanghai Titanos Industry Co., Ltd., one specialized suppliers of titanium dioxide in China)
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD | intratracheal | > 100ug/kg (.1mg/kg) | LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" | Industrial Health. Vol. 35, Pg. 61, 1997. |
However, there is one form of mineral or mineral extract, including titanium dioxide - ultrafine or nano particles, which needs our special attentions. On the basis of Churg et. al. 's study - "Induction of Fibrogenic Mediators by Fine and Ultrafine Titanium Dioxide in Rat Tracheal Explants" in the college of British Columbia, ultrafine particles of the anatase form of titanium dioxide, less than 0.1 microns, could be pathogenic or disease causing. Besides, according to the comprehensive research by scientists in the United States, the titanium dioxide (TiO2) nanoparticles, seen in our daily life, could cause genetic damage to mice.
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SHANGHAI TITANOS INDUSTRY CO.LTD
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China (Mainland) - Year Established: 2004
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- Business type: Manufacturers
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