1. Identification of substance:
Trade name : Travoprost (Travatan)
Chemical Name : Travoprost (Travatan)
Synonyms : Travatan
Product Number : S1554
Hazardous Ingredient : Travoprost (Travatan)
CAS Registry Number : 157283-68-6
Molecular Weight : 500.55
Molecular Formula : C₂₆H₃₅F₃O₆
Manufacturer/Supplier : HANGZHOU HOLYPHARM BIOTECH CO.,LTD

2. Hazards identification:
Hazard Description: Toxic. Contains a pharmaceutically active ingredient. Handling should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

3.Fire fighting measures:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: emits toxic fumes such as carbon monoxide, etc.

4. First aid measures:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration.
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician.
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician.
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician.

5. Handling and storage:
Information for safe handling: avoid inhalation and contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20°C

6. Stability and reactivity:
Stability:stable if stored as directed; avoid strong oxidizing agents.
Thermal decomposition / conditions to be avoided:protect from light and heat.
Dangerous products of decomposition:thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.

7. Physical and chemical properties:
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
Flash Point 17,000 °C Method: closed cup

8. Accidental release measures:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves.
Measures for cleaning/collecting:absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13.

9. Exposure controls and personal protection:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

10. Disposal consideration:
Dispose of in accordance with prevailing country, federal, state and local regulations.

11. Transport information:
DOT: Non-Hazardous for transport:this substance is considered to be non-hazardous for transport
IATA class: Non-Hazardous for transport:this substance is considered to be non-hazardous for transport

12. Regulations:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear protective clothing, gloves and eye/face protection
R28: Very toxic if swallowed
R38: Irritating to skin
R41: Risk of serious damages to eyes
R48: Toxic; danger of serious damage to health by prolonged exposure
R62: Possible risk of impaired fertility
R63: Possible risk of harm to unborn child

13. Toxicological Information:
SIGNS AND SYMPTOMS OF EXPOSURE:
Can cause CNS depression. Exposure can cause: Narcotic effect. Nausea, headache, and vomiting. Damage to the heart. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

ROUTE OF EXPOSURE:
Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: May be harmful if swallowed.

TARGET ORGAN INFORMATION:
Nerves. Liver. Heart.

CHRONIC EXPOSURE - CARCINOGEN:
Result: This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification.

14. Other information:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user.