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Medical uses of cholestyramine

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    Cholestyramine or colestyramine (Questran, Questran Light, Cholybar) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means that it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix.

     

     

    Cholestyramine resin belongs to the class of medications known as bile acid sequestrants. When used along with changes to diet and exercise, this medication helps to reduce cholesterol levels in the blood. It works by binding to cholesterol-like substances called bile acids in the intestines and preventing them from being absorbed into the body.

     

     

    Cholestyramine is also used to prevent diarrhea in Crohn's disease patients who have undergone ileal resection. The terminal portion of the small bowel (ileum) is where bile acids are reabsorbed. When this section is removed, the bile acids pass into the large bowel and attract water due to their osmotic effect, causing diarrhea. Cholestyramine prevents this increase in water by making the bile acids insoluble and osmotically inactive.

     

    Patient teaching

     

    Tell patient to take drug 1 hour before or 4 to 6 hours after other drugs.


    • Teach patient about role of diet in controlling cholesterol level and preventing constipation.

    • Instruct patient to avoid inhaling or ingesting raw powder. Tell him to mix powder with food, juice, or milk before consuming.

    • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.
     

     

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