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Atosiban acetate

What is Atosiban acetate and its side effects.
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    1. The overview of Atosiban acetate

    Atosiban acetate (CAS NO. 90779-69-4)
     is an inhibitor of the hormones oxytocin and vasopressin. In rats and guinea pigs, atosiban acetate was shown to bind to oxytocin receptors, to decrease the frequency of contractions and the tone of the uterine musculature, resulting in a suppression of uterine contractions. Tractocile is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. 

    2. The development of Atosiban acetate and its side effects

    In 1985, CAP 581 was developed by Ferring Pharmaceuticals in Sweden and first reported in the literature. But a 2005 systematic review by the Cochrane Collaboration showed that while atosiban had fewer side-effects than alternative drugs (such as ritodrine), it was no better than placebo in the major outcomes, and in one study showed worse neonatal outcomes. The reviewers suggest nifedipine may be more promising. 

    Some atosiban side effects may be serious while others may only be a mild inconvenience. Very occasionally, certain side-effects can be beneficial. 
    Nausea is the very common which will appears on more than 10% of people who take atosiban acetate. 
    1%-10% of people who take atosiban acetate will have symptoms such as dizziness, faster heart rate, headaches, hot flushes, increased blood sugar levels, injection site problems, lowered blood pressure and vomiting. 
    0.1%-1% of people will have little difficulty sleeping, fever, itching and skin rash or rashes. 
    0.01%-0.1% of people will have some allergic reactions, bleeding from the uterus and decreased uterine muscle tone. 

    Everyone's reaction to a medicine is different. Hence, please tell your prescriber or pharmacist if you are having problems with your medicine.

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