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Aliskiren

What is Aliskiren and its basic properties and its usage.
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    1. What it Aliskiren?
    Aliskiren (CAS NO.173334-57-1)
    whose chemicl name is (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride is an orally active renin inhibitor licensed for the treatment of essential hypertension. Some people also call it "CGP 60536; CGP60536B; Rasilez; SPP 100; Tekturna". It belongs to Chemical Amines;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Aliskiren intermediates. Aliskiren can be used to make Antihypertensive. Its top quality Aliskiren suppliers are survive in China such as HANGZHOU HOLYPHARM BIOTECH CO.,LTD.

    2. The other properties of Aliskiren
    Aliskiren structure:



    Aliskiren solubility: DMSO

    Others: (1)ACD/LogP: 2.794 ; (2)# of Rule of 5 Violations: 2 ; (3)ACD/LogD (pH 5.5): -0.30 ; (4)ACD/LogD (pH 7.4): 0.12 ; (5)ACD/BCF (pH 5.5): 1.00 ; (6)ACD/BCF (pH 7.4): 1.00 ; (7)ACD/KOC (pH 5.5): 1.00 ; (8)ACD/KOC (pH 7.4): 1.69 ; (9)#H bond acceptors: 9 ; (10)#H bond donors: 6 ; (11)#Freely Rotating Bonds: 21 ; (12)Polar Surface Area: 146.13 Å2 ; (13)Index of Refraction: 1.514 ; (14)Molar Refractivity: 155.539 cm3 ; (15)Molar Volume: 516.977 cm3 ; (16)Polarizability: 61.66 10-24 cm3 ; (17)Surface Tension: 40.5839996337891 dyne/cm ; (18)Density: 1.067 g/cm3 ; (19)Flash Point: 406.402 °C ; (20)Enthalpy of Vaporization: 114.478 kJ/mol ; (21)Boiling Point: 748.374 °C at 760 mmHg ; (22)Vapour Pressure: 0 mmHg at 25°C

    3. The usage of Aliskiren
    Rasilez
     is licensed for the treatment of essential hypertension. It inhibits plasma renin activity directly, thereby reducing generation of angiotensin II. The recommended dose of tekturna is 150mg once daily, which may be increased to 300 mg daily if blood pressure (BP) remains uncontrolled.
     

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