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Aliskiren and its intermediates

What is Aliskiren and the introduction of its related intermediates.
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    1. The overview of Aliskiren
    Aliskiren
    (trade names Tekturna) is the first in a class of drugs called direct renin inhibitors. Its current licensed indication is primary hypertension. Its Molecular Weight is 551.76. Its Chemical Formula is C30H53N3O6Aliskiren has deleted CAS which is 401809-63-0 and 957114-21-5. Aliskiren was co-developed by the Swiss pharmaceutical companies.

    2. Aliskiren related intermediates
    (1) Aliskiren hemifumarate
    Aliskiren hemifumarate
     is a white to slightly yellowish powder with a molecular weight of 609.8 (free base- 551.8). It is highly soluble in water, and freely soluble in methanol, ethanol and isopropanol. Its structural formula is:

    (2) Amlodipine besylate
    Amlodipine besylate
     is a white to pale yellow crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. Its structural formula is:


    (3) Aliskiren Fumarate
    Aliskiren Fumarate
    is a white crystalline powder with a molecular weight of 1219.60.  It is soluble in phosphate buffer, n-Octanol, and highly soluble in water. Its structural formula is:


    HANGZHOU HOLYPHARM BIOTECH CO.,LTD is a professional supplier of active pharmaceutical ingredients and intermediates. Their products have been registered in India, Vietnam, Latin America, Turkey, etc. Aliskiren and its intermediates are their major product. All they can give will be the best to you. Please take it into consideration.

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