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Roflumilast

What is roflumilast and its chemical properties even its manufacturers.
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    1. What is Roflumilast?
    Roflumilast (CAS NO.162401-32-3)
    whose chemical name is 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide is a selective phosphodiesterase 4(PDE4) inhibitor. It is used in antiasthmatic and in treatment of chronic obstructive pulmonary disease. Roflumilast Formula is C17H14Cl2F2N2O3
    Roflumilast Molecular Weight is 403.21. Roflumilast should be store at refrigerator. Roflumilast is a white or off white crystalline powder. It can be used amo.

    On March 1,2011, the FDA approved the chronic obstructive pneumonia drug Daliresp (roflumilast), the drug used daily, can reduce asthma attack frequency or mitigate serious chronic obstructive pneumon.

    2. The other properties of Roflumilast
    Roflumilast Molecular Structure:



    Others: (1)ACD/LogP: 2.305 ; (2)ACD/LogD (pH 5.5): 2.31 ; (3)ACD/LogD (pH 7.4): 2.30 ; (4)ACD/BCF (pH 5.5): 33.25 ; (5)ACD/BCF (pH 7.4): 33.06 ; (6)ACD/KOC (pH 5.5): 427.48 ; (7)ACD/KOC (pH 7.4): 425.01 ; (8)#H bond acceptors: 5 ; (9)#H bond donors: 1 ; (10)#Freely Rotating Bonds: 7 ; (11)Polar Surface Area: 60.45 Å2 ; (12)Index of Refraction: 1.604 ; (13)Molar Refractivity: 94.2 cm3 ; (14)Molar Volume: 273.969 cm3 ; (15)Polarizability: 37.344 10-24cm3 ; (16)Surface Tension: 51.8139991760254 dyne/cm ; (17)Density: 1.472 g/cm3 ; (18)Flash Point: 214.198 °C ; (19)Enthalpy of Vaporization: 68.604 kJ/mol ; (20)Boiling Point: 430.565 °C at 760 mmHg ; (21)Solubility: Soluble in Chlorform and DMSO.

    3. Roflumilast manufacturer
    HANGZHOU HOLYPHARM BIOTECH CO.,LTD is a professional manufacturers of this product in China. High quality service and the Best price is the purpose of China Roflumilast suppliers. This product had been sold to many phamaceutical companies. Hence, when you are looking for roflumilast, please come to China.

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