Silodosin (Rapaflo)
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1. What is Rapaflo?
Rapaflo (CAS NO.160970-54-7) is the brand name for silodosin whose IUPAC Name is 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-dihydro-1H-indole-7-carboxamide. Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. Since silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers).
On the other side, the high selectivity seems to cause more problems with ejaculation. As α1A adrenoceptor antagonists are being investigated as a means to male birth control due to their ability to inhibit ejaculation but not orgasm, a trial with 15 male volunteers was conducted. While silodosin was completely efficacious in preventing the release of semen in all subjects, 12 out of the 15 patients reported mild discomfort upon orgasm. The men also reported the psychosexual side effect of being strongly dissatisfied by their lack of ejaculation.
2. Silodosin 99 Manufacturers
Silodosin 99 Manufacturers are the main force of silodosin suppliers. Silodosin 99 is one form of silodosin raw material. The active ingredient of Silodosin 99 is silodosin. HANGZHOU HOLYPHARM BIOTECH CO.,LTD is one of the Silodosin 99 Manufacturers and is a professional supplier of active pharmaceutical ingredients and intermediates. They have rich experience on a wide range of chemical reactions and fermentation from multi gram scale to hundred tons scale according to customers' requirement. So when you are seeking the cooperation, please take China Silodosin 99 Manufacturers into consideration.
Verified Supplier
HANGZHOU HOLYPHARM BIOTECH CO.,LTD
- Country: China (Mainland)
- Year Established: 2009
- Business License:
- Business type: Other
- Integral:
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