1. Rapamycin dose

Rapamycin(CAS NO.53123-88-9) is an immunosuppressant drug used to prevent rejection in organ transplantation, it is especially useful in kidney transplants. Rapamycin dose is important in clinical. 

High immunologic risk
Maintenance: 5 mg PO 
Dose adjustments: trough concentrations 10-15 mg/mL until week 52 

Low-to-moderate immunologic risk
Load: 6 mg PO
Load: Up to 15 mg PO
Maintenance: 2 mg PO qDay
<40 kg: load 3 mg/sq.meter PO, maint 1 mg/sq.meter PO qDay
Adjust dose according to serum concentration: 16-24 ng/mL x1 year then 12-20 ng/mL thereafter
May discontinue cyclosporine gradually 2-4 months after transplant in patients with low immunologic risk, & increase dose of sirolimus
 

 2.Rapamycin msds

Section 1. Product and Company Information
Name: Rapamycin (Sirolimus)
CAS Number: 53123-88-9

Section 2. Composition/Information on Ingredient
Chemical Formula: C₅₁H₇₉NO₁₃
 

Section 3. Hazards Identification
Emergency overview caution: Avoid contact and inhalation
Target organ(s): Immune system
HMIS RATING: HEALTH: 1; FLAMMABILITY: 1; REACTIVITY: 0
NFPA HEALTH: 1; FLAMMABILITY: 1; REACTIVITY: 0

Section 4. First Aid Measures
Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately.
Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately
Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately. Provide chemical label and MSDS if possible.
Ingestion: Remove dentures and clear mouth. If person is conscious, rinse mouth with water Call physician or poison control immediately. Provide chemical label and MSDS information if possible.

Section 5. Fire and Explosion Data

Combustion products: CO, CO₂, NO,NO₂,
Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray
Special Firefighting Procedures:
Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
 

Section 6 - Accidental Release Measures
Cleanup Procedures: Wearing appropriate protective gear as outlined under “Protective equipment” wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed
Waste Disposal Method:
Observe all Federal, State and Local regulations concerning the disposal of this product.Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete

Section 7 - Handling and Storage
Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended.
Storage and Handling: This product should be kept in a tightly closed container. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this material Store at -18^oC

Section 8 - Exposure Controls / Personal protection
General: Use only in a chemical fume hood. Safety shower and eye bath. Use adequate ventilation to keep airborne concentrations low
Personal protective equipment
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye:Chemical safety goggles.

Section 9. Physical Data
Appearance: white crystalline powder
Molecular Weight: 914
Melting: 180^oC 
Solubility: DMSO, Ethanol,

Section 10. Stability and Reactivity Data
Stability: This material is stable if stored as directed
Conditions to Avoid: Excess heat, incompatible materials, strong oxidizers
Incompatibles: Reactive with oxidizing agents, acids, alkalis.
Hazardous polymerization: Will not occur

Section 11 - Toxicological Information
TARGET ORGAN(S) OR SYSTEM(S) Immune system:
Signs and sympromps of exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated
Route of exposure Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TOXICITY DATA Oral,Mouse, LD50> 2500 mg/kg
Intraperitoneal,Mouse, LD50=597 mg/kg
CHRONIC EXPOSURE - MUTAGEN Mouse, Dose: 60 UMOL/L, Cell Type: Mouse leukocyte; Mutation test: DNA damage
Mouse, 10 UMOL/L, Cell Type: leukocyte, Mutation test: DNA inhibition

Section 12 - Ecological Data
Ecotoxicological Information: None Available

Section 13 - Disposal Considerations
Appropriate method of disposal of substance or preparation

Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.

Section 14 - Transport Information
US DOT Proper Shipping Name: None
Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport.

IATA Non-Hazardous for Air Transport

Section 15-Regulatory Information
US CLASSIFICATION AND LABEL TEXT US Statements: Caution: Avoid contact and inhalation. Target organ(s): Immune system
UNITED STATES REGULATORY INFORMATION SARA LISTED: No
EU ADDITIONAL CLASSIFICATION Safety Statements: S: 22-24/25: Do not breathe dust. Avoid contact with skin and eyes

Section 16 -Other Information
Disclaimer For R&D use only. Not for drug, household or other uses
For R&D use only. Not for drug, household or other uses. For use only by trained personnel.

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. The burden of safe use of this material rests entirely with the user. Fermentek shall not be held liable or any damage resulting from handling or from contact with the above product.