Epothilone A
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1. Introduction of Epothilone A (CAS NO.152044-53-6)
Epothilone A is the kind of white crystalline powder. Epothilone A iupac name is 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-,(1S,3S,7S,10R,11S,12S,16R)-. Epothilone A Product Categories is Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds. Epothilone A is a new kind of microtubule function inhibitor with an IC50 of 4.4 nM for tubulin polymerization and cytotoxicity.
2. Basic properties of Epothilone A (CAS NO.152044-53-6)
Epothilone A structure:
Epothilone A Formula: C26H39NO6S
Epothilone A Molecular Weight: 493.66
Epothilone A Density: 1.143 g/cm3
Epothilone A Melting Point: 95 °C
Epothilone A Boiling Point: 683.317 °C at 760 mmHg
Epothilone A Flash Point: 367.057 °C
3. What is the epothilone a synthesis of Epothilone A (CAS NO.152044-53-6)?
Epothilones A (1) and B (2) are potent antitumor natural products with a Taxol-like mechanism of action. A total synthesis of epothilone A (1) is reported, which utilized chiral silane-based bond construction methodology to introduce the key C-6 and C-7 stereocenters of fragment 4. The C-15 stereocenter of fragment 5 was established by a lipase-mediated kinetic resolution. The fragments were assembled with a Suzuki coupling reaction and an aldol condensation and cyclized with a Yamaguchi-type macrolactonization reaction. Epothilone a synthesis is as follows:
HANGZHOU HOLYPHARM BIOTECH CO.,LTD is the professional Epothilone A supplier in China. It is a professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products. They are specialized in contract R&D and custom manufacturing. They have rich experience on a wide range of chemical reactions and fermentation from multi gram scale to hundred tons scale according to customers' requirement. HANGZHOU HOLYPHARM can provide: Assay: 99%; Exterior: white crystalline powder; Package: Aluminum bag; Storage: Room temperature.
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HANGZHOU HOLYPHARM BIOTECH CO.,LTD
- Country: China (Mainland)
- Year Established: 2009
- Business License:
- Business type: Other
- Integral:
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