Tosyl chloride (CAS No. 98-59-9) msds detailed information are provided by Hangzhou Chemfar Ltd., which has more than 20 years' experience focused on providing integrated development and manufacturing service to the pharmaceutical and fine chemical industry.

1. PRODUCT AND COMPANY IDENTIFICATION

Product name: Tosyl chloride

2. HAZARDS IDENTIFICATION

Emergency Overview
OSHA Hazards
Irritant
GHS Classification
Acute toxicity, Oral (Category 5)
Skin irritation (Category 2)
Serious eye damage (Category 1)
GHS Label elements, including precautionary statements

Danger
May be harmful if swallowed.
Causes skin irritation.
Causes serious eye damage.

Precautionary statement(s)
P280 Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
May be harmful if inhaled. Causes respiratory tract irritation.
May be harmful if absorbed through skin. Causes skin irritation.
Causes eye irritation.
May be harmful if swallowed.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Formula: C7H7ClO2S
Molecular Weight: 190.65 g/mol

4. FIRST AID MEASURES

General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

5. FIRE-FIGHTING MEASURES

Conditions of flammability
Not flammable or combustible.
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.
Hazardous combustion products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulphur oxides, Hydrogen chloride gas
Further information
Water hydrolyzes material liberating acidic gas which in contact with metal surfaces can generate flammable and/or explosive hydrogen gas.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7. HANDLING AND STORAGE

Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage
Store under inert gas. Keep container tightly closed in a dry and well-ventilated place.
Store under inert gas. Moisture sensitive.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Components with workplace control parameters
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100
(US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Eye protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance: crystalline
Colour: colourless

10. TOXICOLOGICAL INFORMATION

Acute toxicity
Oral LD50
LD50 Oral - rat - 4,680 mg/kg
Inhalation LC50
no data available
Dermal LD50
no data available
Other information on acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity

Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable,
possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or
anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.

Potential health effects

Inhalation
Ingestion
Skin
Eyes
May be harmful if inhaled. Causes respiratory tract irritation.
May be harmful if swallowed.
May be harmful if absorbed through skin. Causes skin irritation.
Causes eye irritation.

Signs and Symptoms of Exposure spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Blistering, Lachrymation, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Synergistic effects
no data available
Additional Information
RTECS: DB8929000

11. ECOLOGICAL INFORMATION

Toxicity
Toxicity to fish
LC50 - Danio rerio (zebra fish) - > 100 mg/l - 96 h
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment

12. DISPOSAL CONSIDERATIONS

Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste m disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

13. TRANSPORT INFORMATION

DOT (US)
UN-Number: 3261 Class: 8 Packing group: III
Proper shipping name: Corrosive solid, acidic, organic, n.o.s. (Tosyl chloride)
Marine pollutant: No
Poison Inhalation Hazard: No
IMDG
UN-Number: 3261 Class: 8 Packing group: III EMS-No: F-A, S-B
Proper shipping name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (Tosyl chloride)
Marine pollutant: No
IATA
UN-Number: 3261 Class: 8 Packing group: III
Proper shipping name: Corrosive solid, acidic, organic, n.o.s. (Tosyl chloride)

14. REGULATORY INFORMATION

OSHA Hazards
Irritant
DSL Status
All components of this product are on the Canadian DSL list.
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold
(De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Acute Health Hazard
Massachusetts Right To Know Components
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components