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velcade

Bortezomib, marketed as Velcade by Millennium Pharmaceuticals, is the first therapeutic proteasome inhibitor to be tested in humans.
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    Bortezomib, marketed as Velcade by Millennium Pharmaceuticals, is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.

    1. The basic information of Bortezomib (velcade)

    CAS NO : 179324-69-7
    Bortezomib Molecular Weight: 384.24
    Molecular Formula: C19H25BN4O4

                                                                                       
    Boiling Point: 130.5°C (266.9°F)
    Melting Point: -23°C (-9.4°F)
    Bortezomib structure:

    2. The process of Bortezomib synthesis

    Hangzhou Holypharm biotech Co.,Ltd is a professional supplier of active pharmaceutical ingredients and intermediates, agrochemicals and Veterinary products at present. The following is the process of Bortezomib synthesis given by them.

     




    3. How velcade (bortezomib) Works


    Velcade is an important option for treating patients with multiple myeloma and patients with relapsed mantle cell lymphoma (MCL) because it gives you another way to fight your disease. Velcade is a type of medicine called a proteasome (pro-tee-uh-zohm) inhibitor. It is the only proteasome inhibitor the FDA has approved.

    Velcade is a proteasome inhibitor that temporarily blocks, or inhibits, proteasomes from breaking down proteins. This causes a buildup of proteins in the cell. When there are too many proteins in the cells, the cells stop growing and die.

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