Synthesis of pyrroles
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1. Brief introduction of pyrroles
Pyrrole ( CAS No. 109-97-7 ) is one of a class of organic heterocyclic compounds of five-membered diunsaturated ring structure composed of four carbon atoms and one nitrogen atom. Pyrrole and its derivatives are widely used as an intermediate in synthesis of pharmaceuticals, medicines, agrochemicals, dyes, photographic chemicals, perfumes and other organic compounds.
2. Synthesis of pyrroles
Nanjing Aily Biotechnology Co.,Ltd., as a specialized company in chemical manufacture and custom synthesis, obtained the following conclusions through the query of the data.
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An operationally simple, practical, and economical Paal-Knorr pyrrole condensation of 2,5-dimethoxytetrahydrofuran with various amines and sulfonamines in water in the presence of a catalytic amount of iron(III) chloride allows the synthesis of N-substituted pyrroles under very mild reaction conditions in good to excellent yields.
A highly efficient Cu-catalyzed tandem C-N bond-forming reaction of 1,4-dihalo-1,3-dienes allows the synthesis of pyrroles and heteroarylpyrroles with a wide variety of functional groups and substitution patterns from readily available precursors.
N-Propargylic β-enaminones are common intermediates for the synthesis of polysubstituted pyrroles and pyridines. In the presence of Cs2CO3 N-propargylic β-enaminones are cyclized to pyrroles in good to high yields, whereas CuBr leads to pyridines.
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NANJING AILY BIOTECHNOLOGY CO.,LTD
- Country: China (Mainland)
- Business type: Lab/Research institutions
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