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6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one Specification

The specification of 86672-58-4 is offered by Shanghai Tangfang Biotechnology Co., Ltd. Purity: 99% Appearance: off-white solid Type: Pharmaceutical Intermediates
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    1. 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
    With the cas number of 86672-58-4, 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one has synonyms of URB 754, 4H-3,1-Benzoxazin-4-one,6-methyl-2-[(4-methylphenyl)amino]-. 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one was originally described as a potent and selective inhibitor of MAG lipase which selectively raises levels of 2-arachidonoylglycerol (2AG). Subsequent studies have shown that that URB-754 does not inhibit recombinant MAG Lipase and that the original activity was due to a contaminant, bis(methylthio)mercurane, in another commercial source.

    2. 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one Specification
    The Information of 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one Specification is offered by Shanghai Tangfang Biotechnology Co., Ltd.
    Purity: 99%
    Appearance: off-white solid
    Type: Pharmaceutical Intermediates
    Density: 1.23 g/cm3
    Melting Point: 238-240 °C
    Boiling Point: 434 °C at 760 mmHg
    Flash Point: 216.3 °C

    3. Use of 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
    6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one is reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme.

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