Spectroscopic studies on the interaction of Azelnidipine (cas 123524-52-7) with bovine serum albumin
-
Add time:08/01/2019 Source:sciencedirect.com
Interaction between Azelnidipine (cas 123524-52-7) and bovine serum albumin (BSA) was investigated by fluorescence spectroscopy and circular dichroism (CD). Azelnidipine effectively quenched the intrinsic fluorescence of BSA via a combination of static and dynamic quenching, forming azelnidipine–BSA complex with binding constant (Ka) of the order of 105. The thermodynamic parameters obtained from van’t Hoff equation revealed that both ΔH° and ΔS° were negative, that is, −49.77 kJ mol−1 and −64.47 J mol−1 K−1, respectively, suggesting that the binding is mainly driven by the enthalpy and hydrogen bonding plays major role in stabilizing azelnidipine–BSA complex. The binding of azelnidipine to BSA leads to changes in the conformation of BSA according to synchronous fluorescence spectra and CD data. The presence of metal ion decreases the binding constant of azelnidipine–BSA complex.
We also recommend Trading Suppliers and Manufacturers of Azelnidipine (cas 123524-52-7). Pls Click Website Link as below: cas 123524-52-7 suppliers
Prev:Enantioselective determination of Azelnidipine (cas 123524-52-7) in human plasma using liquid chromatography–tandem mass spectrometry
Next:Microwave-green synthesis of AlPO-n and SAPO-n (n = 5 and 18) nanosized crystals and their assembly in layers) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Enantioselective determination of Azelnidipine (cas 123524-52-7) in human plasma using liquid chromatography–tandem mass spectrometry07/31/2019
- Effect of Azelnidipine (cas 123524-52-7) and amlodipine on single cell mechanics in mouse cardiomyocytes07/30/2019
- Acute effects of intravenous nifedipine or Azelnidipine (cas 123524-52-7) on open-loop baroreflex static characteristics in rats07/29/2019
- Olmesartan with Azelnidipine (cas 123524-52-7) versus with trichlormethiazide on home blood pressure variability in patients with type II diabetes mellitus07/28/2019
- Solid state characterization of Azelnidipine (cas 123524-52-7)–oxalic acid co-crystal and co-amorphous complexes: The effect of different Azelnidipine (cas 123524-52-7) polymorphs07/27/2019
- Inhibitory effects of losartan and Azelnidipine (cas 123524-52-7) on augmentation of blood pressure variability induced by angiotensin II in rats07/26/2019
- Limonin alleviates macro- and micro-vascular complications of metabolic syndrome in rats: A comparative study with Azelnidipine (cas 123524-52-7)07/25/2019
- Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by Azelnidipine (cas 123524-52-7) and manidipine07/24/2019
- Improved bioavailability of Azelnidipine (cas 123524-52-7) gastro retentive tablets-optimization and in-vivo assessment07/23/2019